Management of advanced stage Hodgkin lymphoma.

Management of advanced stage Hodgkin lymphoma.
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晚期霍奇金淋巴瘤的治疗。

DOI:
10.6004/jnccn.2006.0023
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发表时间:
2006
期刊:
Journal of the National Comprehensive Cancer Network : JNCCN
影响因子:
--
通讯作者:
S. Horning
S. Horning
中科院分区:
--
文献类型:
--
作者:
R. Advani;W. Ai;S. Horning

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虽然晚期霍奇金淋巴瘤是高度可治愈的,但平衡高治愈率与长期毒性是具有挑战性的。ABVD(多柔比星[阿霉素]、博莱霉素、长春碱、达卡巴嗪)是标准化疗方案,具有较高的治愈率和可接受的毒性。斯坦福大学V和BEACOPP(博莱霉素、依托泊苷、多柔比星、环磷酰胺、长春新碱、甲基苄肼和泼尼松)是新的治疗方案,结果令人鼓舞,正在进行随机临床试验。国际预后评分提供了一种临床工具,可以帮助识别可能需要更积极治疗方案的高危疾病患者。巩固放疗在治疗晚期霍奇金淋巴瘤中的作用仍有争议,但它最被接受用于巨大或残留的疾病或短暂化疗后。新的成像工具的开发和整合,如氟脱氧葡萄糖-正电子发射断层扫描成像,可以更精确地评估疾病,并帮助确定哪些患者可能受益于巩固治疗。
Although advanced Hodgkin lymphoma is highly curable, balancing the high cure rate with long-term toxicity is challenging. ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine, dacarbazine) is the standard chemotherapy regimen, producing a high cure rate with acceptable toxicity. Stanford V and BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) are new regimens with encouraging results and are undergoing randomized clinical trials. The International Prognostic Score provides a clinical tool that may help identify patients with high-risk disease who may require a more aggressive regimen. Consolidative radiation's role in managing advanced Hodgkin lymphoma is still controversial, but it is most accepted for bulky or residual disease or after brief chemotherapy. The development and integration of newer imaging tools, such as fluorodeoxyglucose-positron emission tomography imaging, may allow a more precise evaluation of disease and help define which patients might benefit from consolidative treatment.
放疗和辅助 MOPP 试验中霍奇金病治疗后并发死亡。
DOI: 10.7326/0003-4819-109-3-183
发表时间: 1988
影响因子: 39.2
作者:
Hancock,SL;Hoppe,RT;Horning,SJ;Rosenberg,SA
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DOI: 10.1200/jco.2000.18.5.972
发表时间: 2000-03-01
影响因子: 45.3
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DOI: 10.1200/jco.2003.12.086
发表时间: 2003-02-15
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斯坦福 V 和放疗治疗局部广泛和晚期霍奇金病:前瞻性临床试验的成熟结果。
DOI: 10.1200/jco.2002.20.3.630
发表时间: 2002
期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子: --
作者:
Horning,SandraJ;Hoppe,RichardT;Breslin,Sheila;Bartlett,NancyL;Brown,BWilliam;Rosenberg,SaulA
通讯作者: Rosenberg,SaulA