Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
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DOI：
10.1210/jc.86.5.1930
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发表时间：
2001-05-01
影响因子：
5.8
通讯作者：
Tataranni, PA
中科院分区：
文献类型：
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作者：
Weyer, C;Funahashi, T;Tataranni, PA
脂联素是一种新的脂肪特异性蛋白，具有抗动脉粥样硬化和抗炎作用，在患有肥胖症、2型糖尿病和心血管疾病的日本人中被发现降低，这些疾病通常与胰岛素抵抗和高胰岛素血症有关。为了进一步表征脂联素血症与肥胖症、胰岛素敏感性、胰岛素血症和糖耐量的关系，我们测量了23名高加索人和121名皮马印第安人的血浆脂联素浓度、身体组成(双能X射线吸收法)、胰岛素敏感性(M，高胰岛素钳夹)和葡萄糖耐量(75克口服葡萄糖耐量试验)。血浆脂联素水平与体脂百分比(r=-0.43)、腰腿比(r=-0.46)、空腹胰岛素浓度(r=-0.63)、2小时血糖浓度(r=-0.38)呈负相关，与M呈正相关(r=0.59)(P<；0.001)；所有关系在两个民族中都很明显。在多变量分析中，空腹血浆胰岛素浓度、M和腰腿比，而不是体脂百分比或2小时血糖浓度，是脂联素血症的显著独立决定因素，解释了47%的变异(r(2)=0.47)。皮马印第安人和高加索人之间脂联素血症的差异(7.22.6vs.10.2+/-4.3mug/ml，P<；0.0001)以及糖耐量正常、受损和糖尿病的皮马印第安人之间的差异(7.52.7，6.1+/-2.0，5.5+/-1.6mug/ml，P<；；这些结果证实了肥胖和2型糖尿病与不同民族的低血浆脂联素浓度有关，并表明低脂联素血症的程度与胰岛素抵抗和高胰岛素血症的程度比与肥胖和糖耐量异常的程度更密切相关。
Plasma concentrations of adiponectin, a novel adipose-specific pro tein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity, type 2 diabetes, and cardiovascular disease, conditions commonly associated with insulin resistance and hyperinsulinemia.To further characterize the relationship between adiponectinemia and adiposity, insulin sensitivity, insulinemia, and glucose tolerance, we measured plasma adiponectin concentrations, body composition (dual-energy x-ray absorptiometry), insulin sensitivity (M, hyperinsulinemic clamp), and glucose tolerance (75-g oral glucose tolerance test) in 23 Caucasians and 121 Pima Indians, a population with a high propensity for obesity and type 2 diabetes.Plasma adiponectin concentration was negatively correlated with percent body fat (r = -0.43), waist-to-thigh ratio (r = -0.46), fasting plasma insulin concentration (r -0.63), and 2-h glucose concentration (r = -0.38), and positively correlated with M (r = 0.59) (all P < 0.001); all relations were evident in both ethnic groups. In a multivariate analysis, fasting plasma insulin concentration, M, and waist-to-thigh ratio, but not percent body fat or 2-h glucose concentration, were significant independent determinates of adiponectinemia, explaining 47% of the variance (r(2) = 0.47). Differences in adiponectinemia between Pima Indians and Caucasians (7.2 2.6 vs. 10.2 +/- 4.3 mug/ml, P < 0.0001) and between Pima Indians with normal, impaired, and diabetic glucose tolerance (7.5 2.7, 6.1 +/- 2.0, 5.5 +/- 1.6 mug/ml, P < 0.0001) remained significant after adjustment for adiposity, but not after additional adjustment for M or fasting insulin concentration.These results confirm that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to the degree of insulin resistance and hyperinsulinemia than to the degree of adiposity and glucose intolerance.