Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorder.
Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorder.
复制标题
DOI：
10.1097/chi.0b013e3181b395c0
复制
发表时间：
2009-10
影响因子：
13.3
通讯作者：
Levitt JG
中科院分区：
文献类型：
--
作者：
Narr KL;Woods RP;Lin J;Kim J;Phillips OR;Del'Homme M;Caplan R;Toga AW;McCracken JT;Levitt JG
这项横断面研究旨在证实与正常发育的健康受试者相比，先前报道的注意缺陷/多动障碍（ADHD）儿童和青少年层状皮质厚度变化的存在和区域特征。高分辨率MR图像来自22名（19名男性，3名女性;平均年龄：11.7岁）患有ADHD的儿童和青少年以及22名年龄和性别匹配的健康对照受试者（平均年龄：11.7岁）。估计每例受试者的脑组织体积。皮质模式匹配的方法被用来采样测量层状厚度在高空间频率跨同源区域的皮质。体积和厚度的措施进行了比较，在诊断组和不控制一般智力。错误发现率（FDR）校正证实了区域结果。与健康对照组相比，ADHD受试者的总体脑体积、灰质体积和平均皮质厚度显著减少，而白色物质体积在ADHD中显著增加。在额叶、颞叶、顶叶和枕叶联合皮质的大面积区域以及运动皮质的各个方面观察到高度显著的皮质变薄（FDR校正的p <0.0006），但在初级感觉区域内没有观察到。皮质厚度减少是儿童和青少年ADHD的一个强有力的神经解剖学标志。广泛的皮层变薄的观察扩大了早期的横截面研究结果，并提供了进一步的证据，支持ADHD的神经生物学基础延伸到前额叶和皮层下回路之外。
This cross-sectional study sought to confirm the presence and regional profile of previously reported changes in laminar cortical thickness in children and adolescents with Attention Deficit / Hyperactivity Disorder (ADHD) compared to typically developing healthy subjects. High-resolution MR images were obtained from 22 (19 male, 3 female; mean age: 11.7 years) children and adolescents with ADHD and 22 age and sex matched healthy control subjects (mean age: 11.7 years). Brain tissue volumes were estimated for each subject. Cortical pattern matching methods were used to sample measures of laminar thickness at high spatial frequency across homologous regions of cortex. Volume and thickness measures were compared across diagnostic groups with and without controlling for general intelligence. False discovery rate (FDR) correction confirmed regional results. Subjects with ADHD exhibited significant reductions in overall brain volume, gray matter volume and mean cortical thickness compared to healthy controls, while white matter volumes were significantly increased in ADHD. Highly significant cortical thinning (FDR-corrected p < .0006) was observed over large areas of frontal, temporal, parietal and occipital association cortices and aspects of motor cortex, but not within primary sensory regions. Cortical thickness reductions present a robust neuroanatomical marker for child and adolescent ADHD. Observations of widespread cortical thinning expand upon earlier cross-sectional findings and provide further evidence to support that the neurobiological underpinnings of ADHD extend beyond prefrontal and subcortical circuits.