A study validating changes in the Multiple Sclerosis Functional Composite
A study validating changes in the Multiple Sclerosis Functional Composite
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DOI：
10.1001/archneur.59.1.113
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发表时间：
2002-01-01
影响因子：
--
通讯作者：
Polman, CH
中科院分区：
文献类型：
--
作者：
Hoogervorst, ELJ;Kalkers, NF;Polman, CH
目的：为了前瞻性地描述1年的变化之间的关系，神经学家的异常评级的扩展残疾状态量表（EDSS）和功能障碍的观察结果的变化，通过测量的多发性硬化症功能复合（MSFC）在多发性硬化症（MS）的临床评估方法：120例MS患者在我们的门诊招募。使用EDSS和MSFC评估基线和随访时的损伤和残疾。我们研究了总人群和不同亚组的EDSS、MSFC和MSFC组分变化（A）之间的相关性，并分析了MSFC组分变化对EDSS和MSFC.Results变化的贡献：基线时EDSS评分中位数为4.5;随访时为5.0。基线时平均MSFC评分为-0.00;随访时为-0.04。EDSS和MSFC在基线（-0.72）和随访（-0.73）之间存在良好的横截面相关性。DeltaEDSS和DeltaMSFC之间只有弱相关性。虽然DeltaEDSS表现出最强的相关性与腿部功能的变化和弱或没有相关性与认知功能或手臂functions.Conclusion的变化，DeltaMSFC表现出最高的相关性与手臂功能和认知functions.Conclusion的变化：我们的纵向数据表明，MSFC反映了从不同维度的神经功能的变化，这是一个有利的特点相比，EDSS。
Objective: To prospectively characterize the relation between 1-year changes in neurologist ratings of abnormalities as measured by means of the Expanded Disability Status Scale (EDSS) and changes in observations of functional impairment as measured by means of the Multiple Sclerosis Functional Composite (MSFC) in the clinical assessment of multiple sclerosis (MS).Methods: One hundred twenty patients with MS were recruited at our outpatient clinic. Impairment and disability at baseline and follow-up were assessed using the EDSS and MSFC. We studied correlations between change (A) in the EDSS, MSFC, and MSFC components for the total population and different subgroups and analyzed the contribution of change in MSFC components to change in the EDSS and MSFC.Results: Median EDSS score at baseline was 4.5; at follow-up, 5.0. Mean MSFC score at baseline was -0.00; at follow-up, -0.04. Good cross-sectional correlations were found between the EDSS and MSFC at baseline (-0.72) and follow-up (-0.73). Only weak correlations were found between DeltaEDSS and DeltaMSFC. Although DeltaEDSS showed the strongest correlations with change in leg function and weak or no correlation with change in cognitive function or arm function, DeltaMSFC showed the highest correlation with change in arm function and cognitive function.Conclusion: Our longitudinal data indicate that the MSFC reflects change from different dimensions of neurologic functions, which is a favorable characteristic when compared with the EDSS.