Effect of soluble fiber intake in lipid and glucose leves in healthy subjects: a randomized clinical trial
Effect of soluble fiber intake in lipid and glucose leves in healthy subjects: a randomized clinical trial
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DOI：
10.1016/j.diabres.2003.11.005
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发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Hernandez, JMG
中科院分区：
文献类型：
--
作者：
Aller, R;de Luis, DA;Hernandez, JMG
目的：我们工作的目的是进行一项随机临床试验，两种饮食，一种富含纤维（总纤维30 g和可溶性纤维4 g），以研究对健康受试者血脂和血糖水平的影响。研究设计和方法：53名受试者前瞻性随机分为两组（见表1）。第一组接受的饮食与10.4克的纤维给予1.97克的可溶性纤维（果胶，树胶和粘液）和8.13克的不溶性纤维（半纤维素，纤维素和木质素）和组II接受的饮食与30.5克的纤维，其中4.11克是可溶性纤维和25.08克不溶性纤维。对体重和营养摄入进行了前瞻性系列评估（3天书面食物记录）。在基线和3个月时进行这些测定。所有入组受试者均接受以下检查;采集空腹血样，测量总胆固醇、甘油三酯浓度和其他脂质组分、低密度脂蛋白（LDL-胆固醇）、高密度脂蛋白（HDL-胆固醇）、葡萄糖和胰岛素。结果如下：两组的总热量和脂肪消耗量均低于推荐值（热量;组I 1633 +/- 417 kcal/天vs组II 1707.5 +/- 579 kcal/天：ns）和（脂肪;组I 73.4 +/- 22.7 g/天vs组II 72.6 +/- 28 g/天：ns），脂肪酸摄入量无差异。两种膳食中的总纤维摄入量均未达到推荐值，但第II组的总纤维摄入量较高（9.06 +/- 2.7 g/天vs 25.95 +/- 7.12 g/天：P < 0.05）。两种膳食中的可溶性纤维摄入量均未达到推荐值，但第II组中的可溶性纤维摄入量较高（1.7 +/- 0.58 g/d vs 3.5 +/- 0.96 g/d：P < 0.05）。治疗期间，两组的体重均未发生变化。在治疗期间，在组II中检测到LDL-胆固醇和空腹血糖水平较基线的显著变化。低密度脂蛋白胆固醇降低12.8%（P < 0.05），血糖降低12.3%（P < 0.05）。甘油三酯、HDL-胆固醇和胰岛素水平之间未检测到统计学差异。结论：适度增加可溶性纤维摄入量可以改善健康受试者的LDL胆固醇和葡萄糖水平。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The aim of our work was to carry out a randomized clinical trial with two diets, one enriched in fiber (total fiber 30 g and soluble fiber 4 g) to investigate the effect on lipid and glucose levels in healthy subjects. Research design and methods: Fifty-three subjects were prospectively randomized to two groups (see Table 1). Group I received a diet with 10.4 g of fiber given as 1.97 g soluble fiber (pectins, gums and mucilages) and 8.13 g of insoluble fiber (hemicelullose, cellulose and lignins) and Group II received a diet with 30.5 g of fiber of which 4.11 g were soluble fiber and 25.08 g insoluble fiber. Prospective serial assessment of weight and nutritional intake (3 days written food records) were made. These determinations were performed at baseline and at 3 months. All enrolled subjects underwent the following examinations; fasting blood samples were drawn for measurement of total cholesterol, triglyceride concentrations and other lipid fractions, low density lipoprotein (LDL-cholesterol), high density lipoprotein (HDL-cholesterol), glucose, and insulin. Results: Total calorie and fat consumption were lower than recommended in both groups (calories; group I 1633 +/- 417 kcal per day versus group II 1707.5 +/- 579 kcal per day:ns) and (fats; group I 73.4 +/- 22.7 g per day versus group II 72.6 +/- 28 g per day:ns), without differences in fatty acid intake profile. Total fiber intake did not reach that recommended in both diets but it was higher in group II (9.06 +/- 2.7 g per day versus 25.95 +/- 7.12 g per day: P < 0.05). Soluble fiber intake did not reach that recommended in both diets but it was higher in group II (1.7 +/- 0.58 g per day versus 3.5 +/- 0.96 g per day: P < 0.05). Body weight did not change in both groups during treatment. During treatment, in group II a significant change was detected from baseline in LDL-cholesterol and fasting glucose levels. LDL-cholesterol decreased by 12.8% (P < 0.05) and glucose decreased by 12.3% (P < 0.05). No statistical differences were detected among triglycerides, HDL-cholesterol, and insulin levels. Conclusions: Modest increases in soluble fiber intake in healthy subjects improved LDL cholesterol and glucose levels. (C) 2003 Elsevier Ireland Ltd. All rights reserved.