Oxidative Stress in Vivax Malaria
Oxidative Stress in Vivax Malaria
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DOI：
10.3347/kjp.2012.50.4.375
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发表时间：
2012-12-01
影响因子：
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通讯作者：
Yazar, Suleyman
中科院分区：
文献类型：
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作者：
Bilgin, Ramazan;Yalcin, Mustafa S.;Yazar, Suleyman
疟疾仍然是发病率和死亡率的主要原因。疟疾感染中报告的脂质过氧化增加和抗氧化状态可能是疟疾感染期间氧化应激的有用标志。本研究的目的是探讨抗氧化酶在间日疟原虫感染患者和健康对照中对有毒活性氧的作用。对91例间日疟患者进行丙二醛水平、超氧化物歧化酶和谷胱甘肽过氧化物酶活性测定，并与52例对照组进行比较。丙二醛水平8.07+/-2.29 nM/ml，超氧化物歧化酶2.69+/-0.33U/ml，谷胱甘肽过氧化物酶活性49.6+/-3.2U/g Hb，对照组分别为2.72+/-0.50 nM/ml，3.71+/-0.47U/ml，62.3+/-4.3U/g Hb。间日疟患者血清丙二醛水平显著高于健康对照组(P
Malaria is still a leading cause of morbidity and mortality. The increase in lipid peroxidation reported in malaria infection and antioxidant status may be a useful marker of oxidative stress during malaria infection. The aim of this study was to investigate the role of antioxidant enzymes against toxic reactive oxygen species in patients infected with Plasmodium vivax and healthy controls. Malondialdehyde levels, superoxide dismutase, and glutathione peroxidase activities were determined in 91 P vivax patients and compared with 52 controls. Malondialdehyde levels, superoxide dismutase, and glutathione peroxidase activities were 8.07 +/- 2.29 nM/ml, 2.69 +/- 0.33 U/ml, and 49.6 +/- 3.2 U/g Hb in the patient group and 2.72 +/- 0.50 nM/ml, 3.71 +/- 0.47 U/ml, and 62.3 +/- 4.3 U/g Hb in the control group, respectively. Malondialdehyde levels were found statistically significant in patients with vivax malaria higher than in healthy controls (P