Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine
Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine
复制标题
多巴胺水热处理制备的碳点作为有效的荧光传感平台，用于铁（III）离子和多巴胺的无标记检测
DOI：
10.1002/chem.201300042
复制
发表时间：
2013-05-01
影响因子：
4.3
通讯作者：
Qu, Xiaogang
中科院分区：
文献类型：
--
作者：
Qu, Konggang;Wang, Jiasi;Qu, Xiaogang
提出了一种简单、经济、绿色的水热合成路线，以多巴胺为原料合成了光致发光碳纳米颗粒。所制备的纳米颗粒的平均粒径约为3.8nm。CNP的发射光谱较宽，范围为约380 nm（紫色）至约525 nm（绿色），具体取决于激发波长。由于良好的光学性质，CNPs可以很容易地进入A549细胞，并已被用于生物标记和生物成像。最重要的是，所制备的CNP在其表面上含有独特的儿茶酚基团。由于儿茶酚基团对Fe 3+离子的特殊响应，我们进一步证明这种全新的CNPs可以作为一个非常有效的荧光传感平台，用于Fe 3+离子和多巴胺的无标记灵敏和选择性检测，检测限分别低至0.32M和68 nM。新的混合检测策略简单，绿色，并表现出高灵敏度和选择性。该方法已成功地应用于真实的水样中Fe ~（3+）和人尿、血清中多巴胺的测定。
A facile, economic and green one-step hydrothermal synthesis route using dopamine as source towards photoluminescent carbon nanoparticles (CNPs) is proposed. The as-prepared CNPs have an average size about 3.8nm. The emission spectra of the CNPs are broad, ranging from approximately 380 (purple) to approximately 525nm (green), depending on the excitation wavelengths. Due to the favorable optical properties, the CNPs can readily enter into A549 cells and has been used for multicolor biolabeling and bioimaging. Most importantly, the as-prepared CNPs contain distinctive catechol groups on their surfaces. Due to the special response of catechol groups to Fe3+ ions, we further demonstrate that such wholly new CNPs can serve as a very effective fluorescent sensing platform for label-free sensitive and selective detection of Fe3+ ions and dopamine with a detection limit as low as 0.32M and 68nM, respectively. The new mix-and-detect strategy is simple, green, and exhibits high sensitivity and selectivity. The present method was also applied to the determination of Fe3+ ions in real water samples and dopamine in human urine and serum samples successfully.