A comparative phylogenomic analysis of peste des petits ruminants virus isolated from wild and unusual hosts
A comparative phylogenomic analysis of peste des petits ruminants virus isolated from wild and unusual hosts
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DOI：
10.1007/s11033-019-04973-7
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发表时间：
2019-10-01
影响因子：
2.8
通讯作者：
Shabbir, Muhammad Zubair
中科院分区：
文献类型：
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作者：
Aziz-ul-Rahman;Munir, Muhammad;Shabbir, Muhammad Zubair
小反刍动物害虫病毒（PPRV）感染广泛的家养和野生反刍动物，偶尔也感染不寻常的宿主，如骆驼、牛和猪。鉴于其广泛的宿主谱和疾病在几个发展中国家的地方性，阐明其动态病理生物学和不同宿主选择的病毒进化见解是必要的。为此，对所有可用的（n = 37）来自野生和不寻常宿主的PPRV序列进行了组成和计算机分析。通过与同一地理区域的国内小反刍动物毒株比较，对来自野生宿主和特殊宿主的小反刍动物PPRV序列进行系统基因组学和残基分析，发现毒株之间存在密切的亲缘关系。所研究的序列和推断的残基之间没有明显差异，提示这些宿主因素可能在它们对PPRV感染的易感性、免疫反应、发病机制、排泄模式和潜在的临床症状或对临床疾病的抗性中发挥作用。综上所述，比较分析有助于我们对野生和非常见宿主PPRV的分子流行病学的认识，为采取适当的干预策略，特别是在畜禽-野生动物界面采取适当的干预措施提供依据。
Peste des petits ruminants virus (PPRV) infects a wide range of domestic and wild ruminants, and occasionally unusual hosts such as camel, cattle and pig. Given their broad host-spectrum and disease endemicity in several developing countries, it is imperative to elucidate the viral evolutionary insights for their dynamic pathobiology and differential host-selection. For this purpose, a dataset of all available (n = 37) PPRV sequences originating from wild and unusual hosts was composed and in silico analysed. Compared to domestic small ruminant strains of same geographical region, phylogenomic and residue analysis of PPRV sequences originating from wild and unusual hosts revealed a close relationship between strains. A lack of obvious difference among the studied sequences and deduced residues suggests that these are the host factors that may play a role in their susceptibility to PPRV infection, immune response, pathogenesis, excretion patterns and potential clinical signs or resistance to clinical disease. Summarizing together, the comparative analysis enhances our understanding towards molecular epidemiology of the PPRV in wild and unusual hosts for appropriate intervention strategies particularly at livestock-wildlife interface.