Acute olfactory response of Culex mosquitoes to a human- and bird-derived attractant
Acute olfactory response of Culex mosquitoes to a human- and bird-derived attractant
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DOI：
10.1073/pnas.0906932106
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发表时间：
2009-11-03
影响因子：
11.1
通讯作者：
Leal, Walter S.
中科院分区：
文献类型：
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作者：
Syed, Zainulabeuddin;Leal, Walter S.
西尼罗河病毒由库蚊以鸟类和人类为食而传播，已成为北美主要的媒介传播疾病。我们已经鉴定出来自人类和鸟类的天然化合物，这些化合物可以被致倦库蚊 (Cx. quinquefasciatus) 触角上的嗅觉受体神经元 (ORN) 极其灵敏地检测到。其中一种化学信息素壬醛在不同种族背景的鸽子、鸡和人类的气味谱中占主导地位。我们确定了 Cx 上不同感器类型中所有 ORN 类型的特异性和敏感性。 quinquefasciatus 触角。在这里，我们展示了编码天然配体的所有触角 ORN 及其剂量反应功能的综合图谱。壬醛可被大量感器检测到，是迄今为止最有效的刺激物；因此，支持 Cx 的假设。 quinquefasciatus 可以闻到人类和鸟类的气味。壬醛和二氧化碳具有协同作用，因此，使用二元诱饵的诱捕器捕获的库蚊数量明显高于使用单独诱饵的诱捕器。
West Nile virus, which is transmitted by Culex mosquitoes while feeding on birds and humans, has emerged as the dominant vector borne disease in North America. We have identified natural compounds from humans and birds, which are detected with extreme sensitivity by olfactory receptor neurons (ORNs) on the antennae of Culex pipiens quinquefasciatus (Cx. quinquefasciatus). One of these semiochemicals, nonanal, dominates the odorant spectrum of pigeons, chickens, and humans from various ethnic backgrounds. We determined the specificity and sensitivity of all ORN types housed in different sensilla types on Cx. quinquefasciatus antennae. Here, we present a comprehensive map of all antennal ORNs coding natural ligands and their dose-response functions. Nonanal is detected by a large array of sensilla and is by far the most potent stimulus; thus, supporting the assumption that Cx. quinquefasciatus can smell humans and birds. Nonanal and CO2 synergize, thus, leading to significantly higher catches of Culex mosquitoes in traps baited with binary than in those with individual lures.