Receptor editing in developing T cells
Receptor editing in developing T cells
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DOI：
10.1038/79790
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发表时间：
2000-10-01
影响因子：
30.5
通讯作者：
Hogquist, KA
中科院分区：
文献类型：
--
作者：
McGargill, MA;Derbinski, JM;Hogquist, KA
T 细胞发育的一个中心原则假设，如果发育中的胸腺细胞遇到自身抗原，它会通过细胞凋亡被诱导死亡，从而保护生物体免受自身反应性 T 细胞的侵害。我们创建了在胸腺皮质上皮细胞中表达肽抗原的转基因小鼠，然而，这并没有导致特定T细胞的缺失，相反，上皮细胞的抗原呈递导致T细胞受体（TCR）内化并增加内源性TCRα基因座的基因重排，或受体编辑，未成熟T细胞中的这种编辑机制与发生在未成熟T细胞中的机制相似。 未成熟的 B 细胞，对于理解胸腺中的正向和负向选择信号以及自我耐受的限制具有重要意义。
A central tenet of T cell development postulates that if a developing thymocyte encounters self-antigen, it is induced to die via apoptosis, thereby protecting the organism from autoreactive T cells. We created transgenic mice that expressed a peptide antigen in the cortical epithelial cells of the thymus,This did not, however, result in deletion of specific T cells, Instead, antigen presentation by epithelial cells caused T cell receptor (TCR) internalization and increased gene rearrangement at the endogenous TCR alpha locus, or receptor editing,This editing mechanism in immature T cells parallels that which occurs in immature B cells, and has important implications for understanding positive and negative selection signaling in the thymus, and the limits of self-tolerance.