Comparison of Hippocampal Volume Measured Using Magnetic Resonance Imaging in Alzheimer's Disease, Vascular Dementia, Mild Cognitive Impairment and Pseudodementia
Comparison of Hippocampal Volume Measured Using Magnetic Resonance Imaging in Alzheimer's Disease, Vascular Dementia, Mild Cognitive Impairment and Pseudodementia
复制标题
DOI：
10.1177/147323001204000236
复制
发表时间：
2012-03-01
影响因子：
1.6
通讯作者：
Adapinar, B.
中科院分区：
文献类型：
--
作者：
Dolek, N.;Saylisoy, S.;Adapinar, B.
目的：探讨不同类型痴呆与海马体积的关系。方法：通过磁共振成像测量阿尔茨海默病（n = 22）、血管性痴呆（n = 14）、轻度认知障碍（n = 12）或假性痴呆（n = 16）患者和健康对照受试者（n = 11）的海马体积。简易精神状态检查用于根据认知功能对受试者进行分层。研究结果：与对照组相比，阿尔茨海默病患者的海马体积减少了42%，血管性痴呆患者减少了21%，轻度认知障碍患者减少了15%，假性痴呆患者减少了13%。痴呆的严重程度随着海马体积的减小而增加。结论：海马体积的测量可能有助于痴呆亚型之间的区分。海马体积减小与认知功能障碍的程度有关。
OBJECTIVE: To examine the relationship between different types of dementia and hippocampal volume. METHODS: Hippocampal volume was measured by magnetic resonance imaging in patients with Alzheimer's disease (n = 22), vascular dementia (n = 14), mild cognitive impairment (n = 12) or pseudodementia (n = 16), and in healthy control subjects (n = 11). The Mini Mental State Examination was used to stratify subjects according to cognitive function. RESULTS: Hippocampal volume was reduced by 42% in Alzheimer's disease, 21% in vascular dementia, 15% in mild cognitive impairment and 13% in pseudodementia compared with controls. The severity of dementia increased in line with decreasing hippocampal volume. CONCLUSIONS: Measurement of hippocampal volume may facilitate differentiation between dementia subtypes. There was a relationship between reduced hippocampal volume and the degree of cognitive impairment.