Cognitive fatigue during a test requiring sustained attention: a pilot study
Cognitive fatigue during a test requiring sustained attention: a pilot study
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需要持续注意力的测试期间的认知疲劳：一项试点研究
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
M. Mcdermott
中科院分区：
文献类型：
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作者：
S. Schwid;C. M. Tyler;E. Scheid;A. Weinstein;A. Goodman;M. Mcdermott
背景资料：疲劳在多发性硬化症（MS）中很常见，但难以量化疲劳的严重程度阻碍了对其特征，机制和治疗方法的研究。运动疲劳可以客观地测量为持续收缩期间发生的力量下降。在需要持续注意力的任务中，认知能力也会相应下降。目的：客观地测量认知疲劳作为在需要持续注意力的测试中表现的下降。设计/方法：年龄、性别和教育程度相当的临床稳定的MS患者（n=20）和健康对照组（n=21）在两次练习后的一个月内，在间隔4-10天的两次相同的测试中完成了起搏听觉连续记忆测试（PA SAT）和数字排序测试（DOT）。对于每项试验，采用两种预先规定的方法对疲劳进行定量。认知疲劳评估的可靠性进行了评估与组内相关系数（ICC）和结构效度进行了评估，使用相关性与自我报告的疲劳，认知和整体损伤/残疾的措施。结果如下：MS患者在PA SAT的前20个项目上平均正确18.7个项目，在最后20个项目上平均正确17.8个项目，使用不同的测量方法量化为性能下降5.3-5.8%（P =0.01，拒绝零平均下降的零假设）。虽然MS患者作为一个群体在两个阶段表现出类似的下降，IC C相对较低。对照组患者在PA SAT给药期间没有表现出显著的性能下降，但是比较MS患者和对照组的下降的测试没有表现出显著差异。疲劳没有表现出使用DOT，重测信度非常差。结论：MS患者在PASAT给药期间具有客观可测量的认知疲劳。
Background: Fatigue is common in multiple sclerosis (MS), but difficulty quantifying fatigue severity has impeded studies of its characteristics, mechanisms, and therapeutics. Motor fatigue can be objectively measured as the decline in strength occurring during sustained contractio ns. A nalogous declines in cognitive performance occur during tasks requiring sustained attentio n. Objective: To objectively measure cognitive fatigue as a decline in performance during tests requiring sustained attentio n. Design/Methods: Patients with clinically stable MS (n=20) and healthy controls (n=21) with comparable age, gender, and education completed the Paced A uditory Serial A ddition Test (PA SAT) and the Digit O rdering Test (DOT) at two identical test sessions separated by 4-10 days, within a month after two practice sessions. C ognitive fatigue was quantified with two pre-specified methods for each test. The reliability of cognitive fatigue assessments was evaluated with intraclass correlation coefficients (ICC s) and construct validity was evaluated using correlations with measures of self-reported fatigue, cognition, and overall impairment/disability. Results: MS patients had an average of 18.7 items correct on the first 20 items of the PA SAT and 17.8 correct on the last 20 items, quantified as 5.3-5.8% declines in performance using the different measurement methods (P =0.01, rejecting the null hypothesis of zero mean decline). A lthough MS patients as a group demonstrated a similar decline at both sessions, IC C s were relatively low. C ontrol patients did not demonstrate significant declines in performance during PA SAT administration, but tests comparing declines in MS patients and controls did not demonstrate significant differences. Fatigue was not demonstrated using the DOT, and test-retest reliability was very poor. Conclusions: MS patients have objectively measurable cognitive fatigue during administration of the PASAT.
影响因子：
14.5
作者：
COOPER, JA;SAGAR, HJ;SULLIVAN, EV
通讯作者：
SULLIVAN, EV