AMANTADINE EFFECT ON PERIPHERAL AIRWAYS ABNORMALITIES IN INFLUENZA - STUDY IN 15 STUDENTS WITH NATURAL INFLUENZA-A INFECTION
AMANTADINE EFFECT ON PERIPHERAL AIRWAYS ABNORMALITIES IN INFLUENZA - STUDY IN 15 STUDENTS WITH NATURAL INFLUENZA-A INFECTION
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DOI：
10.7326/0003-4819-85-2-177
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发表时间：
1976-01-01
影响因子：
39.2
通讯作者：
SPEERS, DM
中科院分区：
文献类型：
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作者：
LITTLE, JW;HALL, WJ;SPEERS, DM
盐酸金刚烷胺的应用加速了甲型流感的缓解。在无并发症的甲型流感患者中描述了长期的肺功能异常。为了研究金刚烷胺对这些变化的影响，评估了有记录的自然甲型流感患者的胸部检查和X光检查。受试者以随机、双盲的方式接受安慰剂或金刚烷胺。生理学研究包括空气和HeO2混合气体的最大呼气流量容量曲线。所有受试者的空气流速在整个过程中都保持不变。最初，两组在平均HeO2最大呼气流速方面显示出类似的下降。金刚烷胺组表现出更快的生理改善，7d内HeO2流量显著增加(P<；0.05)。安慰剂组的HeO2流量改善率在统计学上没有显著意义。这些研究证实了无并发症甲型流感后的外周呼吸道功能障碍，并表明金刚烷胺与这种功能障碍的加速缓解有关。
Amantadine HCl administration has resulted in accelerated resolution of influenza A illness. Prolonged abnormalities in pulmonary function were described in uncomplicated influenza A. To study the effect of amantadine on these changes, young adults with documented natural influenza A with clear chest examinations and X rays were evaluated. Subjects received placebo or amantadine in random, double-blind fashion. Physiologic studies included maximal expiratory flow volume curves with air and HeO2 mixtures. Air flow rates were unchanged in all subjects throughout. Initially, both groups showed comparable decreases in mean HeO2 maximal expiratory flow rates. The amantadine group showed accelerated physiologic improvement; significant increase in HeO2 flow rates occurred within 7 days (P < 0.05). The rate of improvement in the HeO2 flow rates in the placebo group was not statistically significant. These studies confirm peripheral airways dysfunction after uncomplicated influenza A and suggest that amantadine is associated with accelerated resolution of this dysfunction.