Short toxic methamphetamine schedule impairs object recognition task in male rats
Short toxic methamphetamine schedule impairs object recognition task in male rats
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DOI：
10.1016/s0006-8993(02)02599-4
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发表时间：
2002-06-14
期刊：
影响因子：
2.9
通讯作者：
Luine, VN
中科院分区：
文献类型：
--
作者：
Bisagno, V;Ferguson, D;Luine, VN
在短剂量模型的甲基苯丙胺（MA）制度和单胺和代谢产物后，测试后测量的对象识别和对象放置记忆任务的性能进行了评价。成年雄性大鼠以2小时间隔接受三次10 mg/kg的注射。纹状体DA和5-HT分别减少65%和79%，前额叶、海马、腹侧被盖区和黑质无明显变化。实验组在开放领域以及物体识别和物体放置任务的样本试验中也表现出较少的探索活动。MA组在物体识别试验中的表现也有所下降（1小时和2小时的试验间延迟）。MA组在样本试验中对对象的探索较少，可能表明一般探索驱动力和/或发起行动的缺陷。然而，在空间版本的识别测试（对象放置任务）的实验组执行以及控制组在两个三个延迟（2小时和4小时），即使显着降低总探索时间的样本试验。我们的研究结果表明，短期毒性时间表诱导神经化学的深刻变化（与经典的MA急性毒性模型：四次注射10 mg/kg），但行为任务的选择性下降。(C)2002 Elsevier Science B. V.保留所有权利。
Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and 79%, respectively, no significant changes were found in pre-frontal cortex, hippocampus, ventral tegmental area (VTA) or substantia nigra. The experimental group also showed less exploratory activity in the open field and the sample trials of both object recognition and object placement tasks. MA groups also showed decreased performance in the object recognition trial (1-h and 2-h inter-trial delays). Less exploration of the objects in the sample trial by the MA group might indicate deficits in general exploratory drive and/or to initiate actions. Nevertheless, in the spatial version of the recognition test (object placement task) the experimental group performed as well as the control group in two of the three delays (2 h and 4 h) even with significantly lower total exploration times in the sample trial. Our results demonstrate that a short toxic schedule induced profound changes in neurochemistry (comparable to classic acute toxic models of MA: four injections of 10 mg/kg) but selective declines in behavioral tasks. (C) 2002 Elsevier Science B.V. All rights reserved.