Endometrial and peritoneal macrophages: Expression of activation and adhesion molecules
Endometrial and peritoneal macrophages: Expression of activation and adhesion molecules
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DOI：
10.1111/j.1600-0897.2004.00201.x
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发表时间：
2004-08-01
影响因子：
3.6
通讯作者：
Tamosiunas, V
中科院分区：
文献类型：
--
作者：
Eidukaite, A;Tamosiunas, V
问题：巨噬细胞在组织中高度个体化，它们的活动是全身和局部环境信号的反映。比较月经周期不同时期CD14(+)子宫内膜巨噬细胞表面CD69、CD71和CD54分子的表达与腹腔液巨噬细胞表面受体的表达。方法：采用双色流式细胞术检测腹膜和子宫内膜巨噬细胞表型。结论：CD69、CD71和CD54在子宫内膜巨噬细胞和腹膜巨噬细胞中的表达存在差异。此外，月经周期分泌晚期子宫内膜巨噬细胞的数量增加，表明它们可能在月经中发挥作用。
Problem: Macrophages are highly individualized in tissues and their activities are a reflection of systemic and local environmental signals. The expression of activation (CD69, CD71) and adhesion (CD54) molecules on the surface of CD14(+) endometrial macrophages at various phases of the menstrual cycle was compared with the cell surface receptors of peritoneal fluid macrophages.Method of Study: Two-colour-flow cytometry was used to determine the peritoneal and endometrial macrophage phenotype.Results: Endometrium macrophages expressed a lower level of CD69(+) and CD54(+) macrophages than peritoneal macrophages. However, CD71 receptors displayed similar expression in both macrophage populations, endometrium and peritoneal, except during the proliferative phase.Conclusion: These findings demonstrate the differences between macrophages from endometrium and peritoneal fluid with regard to CD69, CD71 and CD54 expression. In addition, increased numbers of endometrial macrophages in the late secretory phase of the menstrual cycle suggest that they may play a role in, menstruation.