A case-control study of urinary levels of iodine, perchlorate and thiocyanate and risk of papillary thyroid cancer
A case-control study of urinary levels of iodine, perchlorate and thiocyanate and risk of papillary thyroid cancer
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尿碘、高氯酸盐和硫氰酸盐水平与甲状腺乳头状癌风险的病例对照研究
DOI：
10.1016/j.envint.2018.08.024
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发表时间：
2018-11-01
影响因子：
11.8
通讯作者：
Wu, Yongning
中科院分区：
文献类型：
--
作者：
Zhang, Lei;Fang, Congrong;Wu, Yongning
背景：甲状腺癌的发病率最近在全球范围内有所增加。除了辐射暴露，甲状腺癌发病率的潜在危险因素的影响仍然存在争议。Objectives：暴露于碘，高氯酸盐，硫氰酸盐和乳头状甲状腺癌（PTC）的发病率之间的关联进行了评估和危险因素的predicted.Methods：配对病例对照研究进行了包括116个年龄和性别匹配的PTC病例和116个非PTC对照。采用电感耦合等离子体质谱法和超高效液相色谱-串联质谱法测定尿中碘、高氯酸盐和硫氰酸盐浓度。使用单变量条件回归Logistic分析评估尿碘、高氯酸盐和硫氰酸盐浓度与PTC之间的关系，然后使用多变量条件Logistic回归分析和向后逐步选择来预测PTC的危险因素。校正混杂因素和肌酐标准化后，尿碘浓度[比值比（OR）= 11.01，95%置信区间（CI）：1.97-30.52]和高氯酸盐（OR = 2.27，95%CI：1.03-5.03）与PTC的危险性相关，而尿硫氰酸盐浓度呈负相关结论：碘和高氯酸盐暴露量的增加可能影响PTC的发生，而硫氰酸盐暴露量的增加可能有益PTC的发生。
Background: The incidence of thyroid cancer has recently increased worldwide. With the exception of radiation exposure, the effects of potential risk factors on thyroid cancer incidence remain controversial.Objectives: The association between exposure to iodine, perchlorate, and thiocyanate and papillary thyroid cancer (PTC) incidence was evaluated and risk factors were predicted.Methods: A pair-matching case-control study was performed including 116 age-and sex-matched PTC cases and 116 non-PTC controls. Iodine, perchlorate, and thiocyanate concentrations in urine specimens were determined by inductively coupled plasma mass spectrometry and ultra-performance liquid chromatography-tandem mass spectrometry. The association between iodine, perchlorate, and thiocyanate urinary concentrations and PTC was evaluated using univariable conditional regression logistic analysis followed by multivariable conditional logistic regression analyses with backward stepwise selection to predict risk factors for PTC.Results: After adjusting for confounders and creatinine standardization, urinary concentrations of iodine [odds ratio (OR) = 11.01, 95% confidence interval (CI): 1.97-30.52] and perchlorate (OR = 2.27, 95% CI: 1.03-5.03) were associated with the risk of PTC, whereas urinary thiocyanate concentration showed a negative association (OR = 0.24, 95% CI: 0.09-0.65).Conclusions: Increased exposure to iodine and perchlorate may affect PTC development, whereas high thiocyanate exposure may have a beneficial effect.