Recognition and management of fetal alcohol syndrome
Recognition and management of fetal alcohol syndrome
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DOI：
10.1016/j.ntt.2003.07.020
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发表时间：
2003-11-01
影响因子：
2.9
通讯作者：
Kerbeshian, J
中科院分区：
文献类型：
--
作者：
Burd, L;Cotsonas-Hassler, TM;Kerbeshian, J
胎儿酒精综合征（FAS）是发育障碍、神经精神损害和出生缺陷的常见原因。这种疾病是通过存在生长障碍，中枢神经系统功能障碍和颅面特征的特征性模式来识别的。报告的患病率差异很大，最近的估计接近1%的活产婴儿。这些特征的表现因年龄而异。患有FAS的人有很高的共病率：注意缺陷多动障碍（40%），精神发育迟滞（15-20%），学习障碍（25%），言语和语言障碍（30%），感觉障碍（30%），脑瘫（4%），癫痫（8-10%）。出生缺陷很常见。在美国，每年FAS患者的出生队列可能高达39，000例。FAS患者的病因特异性死亡率为6%。这种疾病的治疗费用很高，大多数患者都有终身的损伤。美国每年的医疗费用将接近50亿美元。早期识别和进入适当的治疗方案似乎可以改善结果。预防工作应包括在怀孕前和第一次产前检查时筛查饮酒情况。(C)2003年爱思唯尔公司All rights reserved.
Fetal alcohol syndrome (FAS) is a common cause of developmental disability, neuropsychiatric impairment and birth defects. The disorder is identified by the presence of growth impairment, central nervous system dysfunction, and a characteristic pattern of craniofacial features. The reported prevalence of the disorder varies widely and recent estimates approach 1% of live births. Expression of these features varies by age. People with FAS have high rates of comorbid conditions: attention deficit hyperactivity disorder (40%), mental retardation (15-20%), learning disorders (25%), speech and language disorders (30%), sensory impairment (30%), cerebral palsy (4%), epilepsy (8-10%). Birth defects are common. In the United States, the annual birth cohort of persons with FAS could be as high as 39,000 cases annually. Cause-specific mortality is 6% for patients with FAS. The disorder is expensive to treat and most patients have lifelong impairment. The annual cost of care in the United States would approach US$5.0 billion. Early recognition and entry into appropriate treatment programs appear to improve outcome. Prevention efforts should involve screening for alcohol use prior to pregnancy and at the first prenatal care visit. (C) 2003 Elsevier Inc. All rights reserved.