Lung ventilation- and perfusion-weighted Fourier decomposition magnetic resonance imaging: In vivo validation with hyperpolarized 3He and dynamic contrast-enhanced MRI
Lung ventilation- and perfusion-weighted Fourier decomposition magnetic resonance imaging: In vivo validation with hyperpolarized 3He and dynamic contrast-enhanced MRI
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DOI：
10.1002/mrm.24236
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发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Puderbach, Michael
中科院分区：
文献类型：
--
作者：
Bauman, Grzegorz;Scholz, Alexander;Puderbach, Michael
本研究的目的是在对照动物实验中验证通气加权（VW）和灌注加权（QW）傅里叶分解（FD）磁共振成像（MRI）与超极化3He MRI和动态对比增强灌注（DCE） MRI。3头健康猪在1.5-T MR扫描仪上进行了研究。对于FD MRI，通过对时间分辨肺部图像集进行后处理获得VW和QW图像。注射造影剂后立即进行DCE检查。使用超极化氦氮混合物后获得MRI数据。基线磁共振扫描后，人为产生肺栓塞。重复FD MRI和DCE MRI灌注测量。随后，诱导肺不张和空气潴留，随后进行FD MRI和3He MRI通气测量。用统计学方法比较正常肺组织和病理肺组织的信号强度分布。所有动物在介入手术前使用FD、3He和DCE MRI获得的图像显示通气和灌注均匀。所有MRI技术在相同的解剖位置检测功能缺陷。病理肺实质的VW和QW图像信号强度明显低于健康肺实质。该研究表明，FD MRI作为一种可替代的、无创的、易于实施的技术，可用于评估肺功能的急性变化。《理性医学杂志》，2013。(c) 2012 Wiley期刊有限公司
The purpose of this work was to validate ventilation-weighted (VW) and perfusion-weighted (QW) Fourier decomposition (FD) magnetic resonance imaging (MRI) with hyperpolarized 3He MRI and dynamic contrast-enhanced perfusion (DCE) MRI in a controlled animal experiment. Three healthy pigs were studied on 1.5-T MR scanner. For FD MRI, the VW and QW images were obtained by postprocessing of time-resolved lung image sets. DCE acquisitions were performed immediately after contrast agent injection. 3He MRI data were acquired following the administration of hyperpolarized helium and nitrogen mixture. After baseline MR scans, pulmonary embolism was artificially produced. FD MRI and DCE MRI perfusion measurements were repeated. Subsequently, atelectasis and air trapping were induced, which followed with FD MRI and 3He MRI ventilation measurements. Distributions of signal intensities in healthy and pathologic lung tissue were compared by statistical analysis. Images acquired using FD, 3He, and DCE MRI in all animals before the interventional procedure showed homogeneous ventilation and perfusion. Functional defects were detected by all MRI techniques at identical anatomical locations. Signal intensity in VW and QW images was significantly lower in pathological than in healthy lung parenchyma. The study has shown usefulness of FD MRI as an alternative, noninvasive, and easily implementable technique for the assessment of acute changes in lung function. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.