Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease
Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease
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DOI：
10.1212/wnl.55.9.1396
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发表时间：
2000-11-14
期刊：
影响因子：
9.9
通讯作者：
Morris, JC
中科院分区：
文献类型：
--
作者：
Chapman, T;McKeel, DW;Morris, JC
克雅氏病 (CJD) 的明确诊断需要脑组织分析。脑脊液中 14-3-3 蛋白的阳性检测被认为对克雅氏病患者具有高度敏感性和特异性。作者描述了三名 CSF 14-3-3 检测假阳性或假阴性的患者。建议在克雅氏病的诊断中不要过度依赖这种假定的生物标志物。
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.