Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica
Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica
复制标题
DOI：
10.1271/bbb.69.197
复制
发表时间：
2005-01-01
影响因子：
1.6
通讯作者：
Yonemori, S
中科院分区：
文献类型：
--
作者：
Masuda, T;Yamashita, D;Yonemori, S
The tyrosinase inhibitory activity of methanol extracts of the leaves of 39 plant species growing on the seashore of Iriomote island (Okinawa, Japan) was investigated. The extracts of Hibiscus tiliaceus, Carex pumila, and Garcinia subelliptica showed potent activity among them. The inhibitors in the extract of Garcinia subelliptica were purified by assay-guided fractionation to give two biflavonoids. These were known compounds (2R,3S-5,7,4',5",7",3"',4"'-heptahydroxy flavanone[3-8"] flavone and 5,7,4',5",7",3"',4"'-heptahydroxy[3-8"] biflavanone), although their strong inhibitory activity toward tyrosinase is revealed for the first time in this work. One of these biflavonoids (2R,3S-5,7,4',5",7",3''', 4"'-heptahydroxy flavanone[3-8"] flavone) showed much stronger activity (IC50 2.5 proportional tom) than that of kojic acid (IC50 9.1 proportional tom) when L-tyrosine was used as the substrate.
