RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.
RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.
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发表时间：
2001-10
期刊：
影响因子：
4.6
通讯作者：
H. Enomoto;Peter A. Crawford;A. Gorodinsky;R. Heuckeroth;Eugene M. Johnson;J. Milbrandt
中科院分区：
文献类型：
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作者：
H. Enomoto;Peter A. Crawford;A. Gorodinsky;R. Heuckeroth;Eugene M. Johnson;J. Milbrandt
交感神经轴突使用血管作为到达其最终靶组织的中间路径。分化中的交感神经元和血管之间的初始接触发生在初级交感神经链形成之后，其中交感神经元的前体迁移并沿着沿着或朝向血管投射轴突。我们证明，在视网膜缺陷小鼠，神经元前体在整个交感神经系统不能迁移和项目轴突正确。这些原发性缺陷导致交感神经干的错误路由和交感神经元在发育后期的加速细胞死亡。Artemin在交感神经分化早期的血管中表达，并且可以促进和吸引体外交感神经节的轴突生长。该分析确定RET和artemin作为早期交感神经支配的中枢调节剂。
Sympathetic axons use blood vessels as an intermediate path to reach their final target tissues. The initial contact between differentiating sympathetic neurons and blood vessels occurs following the primary sympathetic chain formation, where precursors of sympathetic neurons migrate and project axons along or toward blood vessels. We demonstrate that, in Ret-deficient mice, neuronal precursors throughout the entire sympathetic nervous system fail to migrate and project axons properly. These primary deficits lead to mis-routing of sympathetic nerve trunks and accelerated cell death of sympathetic neurons later in development. Artemin is expressed in blood vessels during periods of early sympathetic differentiation, and can promote and attract axonal growth of the sympathetic ganglion in vitro. This analysis identifies RET and artemin as central regulators of early sympathetic innervation.