Regulation of protein kinase C
Regulation of protein kinase C
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DOI：
10.1016/s0955-0674(97)80058-0
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发表时间：
1997-04-01
影响因子：
7.5
通讯作者：
Newton, AC
中科院分区：
文献类型：
--
作者：
Newton, AC
自从二十年前发现蛋白激酶 C 被脂质第二信使二酰甘油激活以来，它一直受到人们的关注。尽管蛋白激酶 C 一直存在，但其同工酶在特定细胞过程中的调节和特定作用仍在深入研究中。蛋白激酶 C 调节模块结构的阐明、磷酸化调节酶的发现以及靶向机制的确定，使得过去的一年成为揭示这类普遍存在的酶如何运作的重要一年。
Protein kinase C has been in the spotlight since the discovery two decades ago that it is activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring stage presence, the regulation and specific roles of its isozymes in defined cellular processes are still under intense investigation. Elucidation of the structures of protein kinase C's regulatory modules, the discovery that phosphorylation regulates the enzyme, and the identification of targeting mechanisms have made the past year a significant one for unveiling how this ubiquitous class of enzymes operates.