Microbiota-immune interactions in asthma pathogenesis and phenotype.

Microbiota-immune interactions in asthma pathogenesis and phenotype.
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DOI:
10.1016/j.coi.2020.03.012
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发表时间:
2020-10
影响因子:
7
通讯作者:
--
中科院分区:
医学2区
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--
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粘膜表面微生物群落的复杂性和机制作用现在才开始被理解。它们对宿主代谢、发育和对感染性和惰性刺激的免疫反应的影响可能与已建立的微生物组内这些群落的代谢功能密切相关。微生物群落的结构和功能在早期和一生中都受到许多环境因素、暴露、饮食和疾病的影响。了解微生物组在健康期间如何影响宿主可能与了解它如何影响哮喘疾病易感性和严重程度一样重要。
The complexity and the mechanistic role of microbial communities at mucosal surfaces are only now beginning to be understood. Their impact on host metabolism, development, and immune responses to infectious and inert stimuli may be centrally linked to the metabolic functions of these communities within the established microbiome. The structure and function of microbial communities are influenced both early and throughout life by many environmental factors, exposures, diet, and disease. Understanding how the microbiome influences the host during health is likely just as important as understanding how it influences asthmatic disease predisposition and severity.
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