A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo
A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo
复制标题
DOI：
10.1016/s1471-4906(00)01844-5
复制
发表时间：
2001-03-01
影响因子：
16.8
通讯作者：
Le Poole, IC
中科院分区：
文献类型：
--
作者：
Das, PK;van den Wijngaard, RMJGJ;Le Poole, IC
白癜风是一种皮肤病，其中黑素细胞（MC）从皮损表皮中根除。导致色素的毁损性损失。MC被MC反应性T细胞以及其他非免疫和免疫成分破坏。白癜风中观察到的自身免疫与黑色素瘤免疫监测中观察到的肿瘤免疫之间存在相似性。对这些机制的分析可能会导致白癜风和黑色素瘤的新疗法的发展。
Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis. resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.