A small-molecule antagonist of the hedgehog signaling pathway
A small-molecule antagonist of the hedgehog signaling pathway
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DOI：
10.1002/cbic.200700403
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发表时间：
2007-11-05
期刊：
影响因子：
3.2
通讯作者：
Schultz, Peter G.
中科院分区：
文献类型：
--
作者：
Lee, Jongkook;Wu, Xu;Schultz, Peter G.
刺猬影子。通过基于细胞的化学库筛选，JK184（如图所示）被鉴定为 Hedgehog 信号传导的拮抗剂。生化和细胞实验的结果表明，JK1 84 通过抑制 IV 类乙醇脱氢酶发挥作用。该分子应该作为研究 Hedgehog 信号传导的有用工具。
Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK1 84 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.