Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults:: A retrospective study from the rare cancer network
Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults:: A retrospective study from the rare cancer network
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DOI：
10.1016/j.ijrobp.2006.04.035
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发表时间：
2006-09-01
影响因子：
7
通讯作者：
Mirimanoff, Rene O.
中科院分区：
文献类型：
--
作者：
Weber, Damien C.;Miller, Robert C.;Mirimanoff, Rene O.
目的：本研究的目的是评估结果与小脑胶质母细胞瘤（GBM）治疗的患者在15个机构的罕见Cancer Network.Methods和材料：从一系列的45例成人小脑GBM患者的数据收集在一个回顾性多中心研究。中位年龄为50.3岁。9例（20%）患者观察到脑干受侵。36例患者接受了放疗（RT）（7例患者同时接受化疗）。8例患者在RT后给予辅助化疗。中位RT剂量为59.4戈伊。中位随访时间为7.2个月（范围，3.4-39.0）。1年和2年精算总生存率分别为37.8%和14.7%，且受挽救治疗的显著影响（p = 0.048），肿瘤体积（p = 0.044），神经外科切除范围（p = 0.019）、脑干侵犯（p = 0.0013）、术后额外治疗（p < 0.001）和初始治疗完成（p < 0.001）。所有患者均发生局部进展：分别有8例和22例进展伴和不伴远端失败。1年和2年的精算无进展生存率分别为25%和10.7%，并且受脑干浸润（p = 0.002）、术后额外治疗（p = 0.0016）和初始治疗完成（p < 0.001）的显著影响。多变量分析显示，手术范围（p = 0.03）和脑干侵犯（p = 0.02）对生存率有负面影响。结论：在这项多中心回顾性研究中，观察到的失败模式在所有病例中均为局部，但大约1/4的患者出现了小脑外成分。脑干侵犯在相当数量的患者中观察到，并且是不良预后因素。(c)2006年爱思唯尔公司
Purpose: The aim of this study was to assess the outcome in patients with cerebellar glioblastoma (GBM) treated in 15 institutions of the Rare Cancer Network.Methods and Materials: Data from a series of 45 adult patients with cerebellar GBM were collected in a retrospective multicenter study. Median age was 50.3 years. Brainstem invasion was observed in 9 (20%) patients. Radiotherapy (RT) was administered to 36 patients (with concomitant chemotherapy, 7 patients). Adjuvant chemotherapy after RT was administered in 8 patients. Median RT dose was 59.4 Gy. Median follow-up was 7.2 months (range, 3.4-39.0).Results: The 1-year and 2-year actuarial overall survival rate was 37.8% and 14.7%, respectively, and was significantly influenced by salvage treatment (p = 0.048), tumor volume (p = 0.044), extent of neurosurgical resection (p = 0.019), brainstem invasion (p = 0.0013), additional treatment after surgery (p < 0.001), and completion of the initial treatment (p < 0.001) on univariate analysis. All patients experienced local progression: 8 and 22 had progression with and without a distant failure, respectively. The 1- and 2-year actuarial progression free survival was 25% and 10.7%, respectively, and was significantly influenced by brainstem invasion (p = 0.002), additional treatment after surgery (p = 0.0016), and completion of the initial treatment (p < 0.001). On multivariate analysis, survival was negatively influenced by the extent of surgery (p = 0.03) and brainstem invasion (p = 0.02).Conclusions: In this multicenter retrospective study, the observed pattern of failure was local in all cases, but approximately 1 patient of 4 presented with an extracerebellar component. Brainstem invasion was observed in a substantial number of patients and was an adverse prognostic factor. (c) 2006 Elsevier Inc.