The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients
The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients
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趋化因子CXCL9表达与结直肠癌患者更好的预后相关
DOI：
10.1016/j.biopha.2015.12.021
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发表时间：
2016-03-01
影响因子：
7.5
通讯作者：
Wang, Yu
中科院分区：
文献类型：
--
作者：
Wu, Zhenqian;Huang, Xiuyan;Wang, Yu
趋化因子CXCL9已被证明在人类恶性肿瘤的发展中发挥重要作用。然而，其在癌症患者中的预后意义尚不清楚，其在结直肠癌（CRC）患者中的作用也知之甚少。在本研究中，我们发现CXCL9在原发结直肠肿瘤组织中的相对mRNA表达水平显著高于相应的正常结肠组织。130例原发性结直肠癌患者中102例也通过免疫化学检测到CXCL9蛋白的表达。因此，CXCL9可能在结直肠癌的进展中发挥重要作用。通过分析患者临床病理因素与CXCL9蛋白表达的相关性，我们发现CXCL9的表达与结直肠癌患者的肿瘤分化、肿瘤侵袭、淋巴结转移、远处转移、血管侵袭有显著相关性，而与年龄、性别、肿瘤位置、肿瘤大小等其他因素无显著相关性。此外，通过Kaplan- Meier法以及Cox单因素和多因素风险回归模型，我们发现CXCL9表达越高，总生存率越高，CXCL9表达是结直肠癌患者预后的重要独立因素。因此，CXCL9是预测结直肠癌患者临床预后的有效指标。(C) 2016年由Elsevier Masson SAS出版。
The chemokine CXCL9 has been demonstrated to play an important role in the development of human malignancies. However, its prognostic significance in cancer patients remains unclear and less is known about its role in colonrectal carcinoma (CRC) patients. In this study, we found that the relative mRNA expression level of CXCL9 in primary colorectal tumor tissues was significantly higher than that in corresponding normal colon tissues. CXCL9 protein expression was also detected in 102 of 130 primary CRC patients by immunochemistry. Thus, CXCL9 might play a vital role in the progression of colorectal cancer. By analyzing the correlation between clinicopathological factors of patients and expression of CXCL9 protein, we showed that the expression of CXCL9 was significantly associated with tumor differentiation, tumor invasion, lymph node metastasis, distant metastasis, and vascular invasion, but not with other factors of CRC patients including age, gender, tumor location and tumor size. Furthermore, by performing Kaplan- Meier method as well as Cox's univariate and multivariate hazard regression model, we found that the higher the CXCL9 expression, the higher overall survival rate was observed, and CXCL9 expression was a significant independent prognostic factor for CRC patients. Therefore, CXCL9 is a useful predictor of better clinical outcome in CRC patients. (C) 2016 Published by Elsevier Masson SAS.