KETONE-BODY TURNOVER DURING AND AFTER EXERCISE IN OVERNIGHT-FASTED AND STARVED HUMANS
KETONE-BODY TURNOVER DURING AND AFTER EXERCISE IN OVERNIGHT-FASTED AND STARVED HUMANS
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DOI：
10.1152/ajpendo.1983.245.4.e318
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
BALASSE, EO
中科院分区：
文献类型：
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作者：
FERY, F;BALASSE, EO
酮体的浓度和它们的转运速率（用β-酮的输注估计）[14 C]-羟基丁酸酯）在运动前、运动中和运动后在禁食过夜和禁食3-5天的受试者中进行测定，这些受试者在4 ℃在跑步机上行走2小时。其最大VO 2 [最大O2摄取量]的50%。在整夜禁食的受试者中，运动增加周转率（2小时后+125%）和浓度从0.20-0.39 mM升高的酮体的代谢清除率。停止运动与酮体水平的显著升高相关（恢复30分钟后+0.73 mM），这与进一步刺激生酮（+19%）和代谢清除率显著下降至运动前值以下有关。饥饿受试者（静息酮水平平均为5.7 mM）对工作的反应是周转率和酮浓度降低，代谢清除率保持不变。运动对生酮和肌酮摄取的反应均受空腹酮症初始程度的显著影响。
Concentration of ketone bodies and their rate of transport (estimated with an infusion of .beta.-[14C]-hydroxybutyrate) were determined before, during and after exercise in overnight-fasted and 3-5 day-fasted subjects who walked on a treadmill for 2 h at .apprx. 50% of their .ovrhdot.VO2 max [maximum O2 uptake]. In overnight-fasted subjects, exercise increased the rate of turnover (+125% after 2 h) and the metabolic clearance rate of ketone bodies whose concentration rose from 0.20-0.39 mM. Discontinuation of exercise was associated with a marked increase in ketone levels (+0.73 mM after 30 min of recovery) that was related to a further stimulation of ketogenesis (+19%) and to a marked drop of the metabolic clearance rate to below preexercise values. Starved subjects (with a resting ketone level averaging 5.7 mM) responded to work by a decrease in the turnover rate and in the concentration of ketones, their metabolic clearance rate remaining unchanged. The response of ketogenesis and muscular ketone uptake to exercise are both markedly influenced by the initial degree of fasting ketosis.