Participation of bone marrow derived cells in cutaneous wound healing
Participation of bone marrow derived cells in cutaneous wound healing
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DOI：
10.1002/jcp.10260
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发表时间：
2003-08-01
影响因子：
5.6
通讯作者：
Quesenberry, P
中科院分区：
文献类型：
--
作者：
Badiavas, EV;Abedi, M;Quesenberry, P
长期以来，骨髓被认为是造血系统再生干细胞的来源。然而，最近的报告表明，骨髓也可能含有早期干细胞，可以分化成其他器官组织，如皮肤。虽然这些研究已经表明骨髓干细胞可以找到进入皮肤的途径，但它们还没有解决骨髓干细胞如何参与皮肤的稳态和再生的动力学。在这份报告中，我们跟踪绿色荧光蛋白（GFP）标记的骨髓移植到非GFP小鼠，以确定骨髓干细胞在皮肤伤口的参与。我们的研究结果表明，有大量的骨髓细胞，交通通过受伤和非受伤的皮肤。创伤刺激骨髓细胞向皮肤的植入，并诱导骨髓衍生的细胞并入并分化成非造血皮肤结构。因此，这份报告表明，骨髓可能是皮肤和其他器官干细胞的宝贵来源。创伤可以刺激骨髓来源的干细胞前往器官并帮助受损组织再生。(C)2003 Wiley-Liss，Inc.
Bone marrow has long been known to be a source of stem cells capable of regeneration of the hematopoeitic system. Recent reports, however, have indicated that bone marrow might also contain early stem cells that can differentiate into other organ tissues such as skin. While these studies have illustrated that bone marrow stem cells could find their way to the skin, they have not addressed the dynamics of how bone marrow stem cells might participate in the homeostatis and regeneration of skin. In this report we followed green fluorescent protein (GFP) labeled bone marrow transplanted into non-GFP mice in order to determine the participation of bone marrow stem cells in cutaneous wounds. Our results indicate that there are a significant number of bone marrow cells that traffic through both wounded and non-wounded skin. Wounding stimulated the engraftment of bone marrow cells to the skin and induced bone marrow derived cells to incorporate into and differentiate into non-hematopoietic skin structures. This report thus illustrates that bone marrow might be a valuable source of stem cells for the skin and possibly other organs. Wounding could be a stimulus for bone marrow derived stem cells to travel to organs and aid in the regeneration of damaged tissue. (C) 2003 Wiley-Liss, Inc.