Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia
Regulation of neurogenesis by neurotrophins in developing spinal sensory ganglia
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DOI：
10.1016/s0361-9230(01)00767-5
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发表时间：
2002-04-01
影响因子：
3.8
通讯作者：
Soriano, M
中科院分区：
文献类型：
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作者：
Fariñas, I;Cano-Jaimez, M;Soriano, M
脊髓感觉神经节中的神经元和神经胶质细胞来源于多能神经嵴源性干细胞。与中枢神经系统中的神经祖细胞相反，神经嵴祖细胞在整个神经发生期与分化的感觉神经元共存。因此，发展中的感觉神经节是有利的，以确定可能的影响，细胞间的相互作用，在前体增殖和神经发生的调节。神经营养因子是发育中的脊椎动物神经系统中神经元存活的重要调节因子，此外，它们似乎影响体外前体行为。对携带神经营养因子基因突变的小鼠的研究提供了一个很好的系统，可以分析这些因素对不同发育神经群体的重要作用。(C)2002年爱思唯尔科技有限公司
Neurons and glia in spinal sensory ganglia derive from multipotent neural crest-derived stem cells. In contrast to neural progenitor cells in the central nervous system, neural crest progenitors coexist with differentiated sensory neurons all throughout the neurogenic period. Thus, developing sensory ganglia are advantageous for determining the possible influence of cell-cell interactions in the regulation of precursor proliferation and neurogenesis. Neurotrophins are important regulators of neuronal survival in the developing vertebrate nervous system and, in addition, they appear to influence precursor behavior in vitro. Studies in mice carrying mutations in neurotrophin genes provide a good system in which to analyze essential actions of these factors on the different developing neural populations. (C) 2002 Elsevier Science Inc.