Antianginal efficacy of oral therapy with isosorbide dinitrate capsules. Prolonged benefit shown by exercise testing in patients with ischemic heart disease.
Antianginal efficacy of oral therapy with isosorbide dinitrate capsules. Prolonged benefit shown by exercise testing in patients with ischemic heart disease.
复制标题
硝酸异山梨酯胶囊口服治疗的抗心绞痛疗效。
DOI：
10.1378/chest.73.3.327
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发表时间：
1978
期刊：
影响因子：
9.6
通讯作者：
Anthony N. DeMaria
中科院分区：
文献类型：
--
作者：
Garrett Lee;Dean T. Mason;Ezra A. Amsterdam;Richard R. Miller;Anthony N. DeMaria
虽然缓释硝酸盐已经以胶囊形式引入，试图达到长期的治疗作用，但没有关于这种制剂在心绞痛患者中的疗效的客观数据。因此，我们对28例缺血性心脏病患者进行了双盲研究，研究硝酸异山梨酯胶囊治疗对给药后2小时和6小时运动耐量的影响。在最后一剂硝酸异山梨酯口服40毫克胶囊之前和之后2小时或6小时进行最大分级多阶段跑步机运动，每8小时口服一次，持续一个月。与安慰剂相比，以这种方式施用硝酸异山梨酯可显著减少心绞痛发作。与对照组相比，10例患者在接受硝酸异山梨酯治疗2小时后进行运动测试，运动时间（311 ~ 386秒）和最大耗氧量（21.5 ~ 24.4 ml/kg/min）显著增加（P < 0.05）
Although sustained-release nitrates have been introduced in capsule form in an attempt to achieve prolonged therapeutic action, no objective data are available regarding the efficacy of such preparations in patients with angina pectoris. Therefore, we performed a double-blind investigation to study the effects of therapy with capsules of isosorbide dinitrate upon the exercise tolerance at two and six hours after administration in 28 patients with ischemic heart disease. Maximal graded multistage treadmill exercise was performed before and at two or six hours following the last dose of isosorbide dinitrate administered orally as 40-mg capsules every eight hours for one month. Isosorbide dinitrate administered in this fashion resulted in a significant reduction in anginal episodes, as compared with placebo. As compared to control, ten patients who underwent exercise testing two hours after therapy with isosorbide dinitrate manifested significantly increased duration of exercise (311 to 386 seconds) and maximal oxygen consumption (21.5 to 24.4 ml/kg/min) (both P