A rare case of lung carcinoma acquires multidrug-resistant Klebsiella pneumoniae pneumonia radiologically mimicking metastasis caused by nivolumab therapy-associated neutropenia.
A rare case of lung carcinoma acquires multidrug-resistant Klebsiella pneumoniae pneumonia radiologically mimicking metastasis caused by nivolumab therapy-associated neutropenia.
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一例罕见的肺癌获得多重耐药肺炎克雷伯菌肺炎，放射学上与纳武单抗治疗相关的中性粒细胞减少症引起的转移相似
DOI：
10.2147/tcrm.s144681
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发表时间：
2017
影响因子：
2.8
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Liu C;Ding L;Zhu YH;Chen C
肺炎克雷伯菌医院感染，特别是那些由于多重耐药菌株，正在越来越多地检测到。在这份报告中，我们介绍了一例63岁男性肺鳞癌患者，由于一线化疗失败而接受纳武利尤单抗治疗。该报告还证实了nivolumab治疗与中性粒细胞减少症的相关性，并支持使用替加环素和美罗培南联合治疗由多重耐药克雷伯菌引起的住院获得性肺炎。肺炎。这也意味着需要对疑似转移或复发癌的肺癌患者进行进一步评估，并且抗生素治疗在排除潜在的肺部感染方面是有价值的，因为可能存在住院获得性肺炎的风险。
Nosocomial infections by Klebsiella pneumoniae, especially those due to multidrug-resistant strains, are being increasingly detected. In this report, we present the case of a 63-year-old man with lung squamous carcinoma who received nivolumab therapy due to failure of first-line chemotherapy. This report also demonstrates an association of nivolumab therapy and neutropenia, and supports the use of a combination of tigecycline and meropenem in managing hospitalization-acquired pneumonia caused by multidrug-resistant K. pneumoniae. It also implicates that a further evaluation is required in lung cancer patients with a suspected metastatic or recurrent carcinoma, and an antibiotic therapy is valuable in ruling out a potential lung infection since a risk of hospitalization-acquired pneumonia may exist.
影响因子：
2.7
作者：
Chen C;Zhu YH;Qian HY;Huang JA
通讯作者：
Huang JA