Controllable microfluidic production of multicomponent multiple emulsions
Controllable microfluidic production of multicomponent multiple emulsions
复制标题
多组分多重乳液的可控微流体生产
DOI：
10.1039/c1lc20065h
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发表时间：
2011-01-01
期刊：
影响因子：
6.1
通讯作者：
Chu, Liang-Yin
中科院分区：
文献类型：
--
作者：
Wang, Wei;Xie, Rui;Chu, Liang-Yin
由三个构建块的组合构成的分层且可扩展的微流体装置能够高度控制多组分多重乳液的生成。可以精确控制液滴的数量、比例和尺寸，每个液滴具有独立地共同包封在相同水平中的不同内容物。构建模块是液滴制造器、连接器和液体提取器;这些的组合使装置能够按比例放大，以产生具有异常多样化结构的高阶多组分多重乳液。这些多组分多重乳液提供了一个通用的和有前途的平台，用于精确封装不相容的活性物质或化学品，用于协同递送和生物化学和化学反应，以及用于设计具有受控内相的多隔室材料。
A hierarchical and scalable microfluidic device constructed from a combination of three building blocks enables highly controlled generation of multicomponent multiple emulsions. The number, ratio and size of droplets, each with distinct contents being independently co-encapsulated in the same level, can be precisely controlled. The building blocks are a drop maker, a connector and a liquid extractor; combinations of these enable the scale-up of the device to create higher-order multicomponent multiple emulsions with exceptionally diverse structures. These multicomponent multiple emulsions offer a versatile and promising platform for precise encapsulation of incompatible actives or chemicals, for synergistic delivery and biochemical and chemical reactions, and for engineering multicompartment materials with controlled internal phases.