Age and Other Risk Factors for Corneal Infiltrative and Inflammatory Events in Young Soft Contact Lens Wearers from the Contact Lens Assessment in Youth (CLAY) Study
Age and Other Risk Factors for Corneal Infiltrative and Inflammatory Events in Young Soft Contact Lens Wearers from the Contact Lens Assessment in Youth (CLAY) Study
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DOI：
10.1167/iovs.10-7018
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发表时间：
2011-08-01
影响因子：
4.4
通讯作者：
McMahon, Timothy T.
中科院分区：
文献类型：
--
作者：
Chalmers, Robin L.;Wagner, Heidi;McMahon, Timothy T.
目的。描述年轻的软性接触镜(SCL)配戴者发生角膜浸润性和炎症事件(CIES)的年龄和其他危险因素，并模拟年龄相关的风险。方法：一项多中心的回顾性图表回顾，从2006年1月至2009年9月收集了3549名SCL配戴者(首次观察时年龄8-33岁，过度抽样+8.00-12.00D；18岁)的CIES。这篇综述记录了年龄、性别、戴过的SCL、使用过的镜片护理产品以及SCL的佩戴史。事件诊断由蒙面佩戴者身份、年龄和SCL参数的评审员做出一致裁决。随后在多变量广义估计方程中检验了显著的CIE的单变量危险因素。结果：在观察4663个SCL年的14,305次访问中，168名佩戴者中有187个CIE。年龄是一个重要的非线性风险因素，在15至25岁之间达到顶峰(P<；0.008)。使用不到1年的SCL是保护性的，而不是穿戴更长的年限(P<；0.0003)。在多变量模型(P<；0.0001)中，使用多用途护理产品(2.86x)、硅胶水凝胶(1.85x)和长时间佩戴(2.37x)与CIEs显著相关(P<；0.0001)。结论：患者年龄、佩戴镜片年限、使用多用途护理产品、硅胶水凝胶和长时间佩戴均与CIEs伴SCL磨损显著相关。与青少年和年轻人相比，在8至15岁的年轻患者中使用SCLS与浸润性事件的风险较低相关。在安全性方面，SCLS似乎是一种可以接受的方法，可以提供旨在控制未来儿童和青少年近视进展的光学设备。(投资眼科VS科学。2011年；52：6690-6696)doi：10.1167/iovs.10-7018
PURPOSE. To describe age and other risk factors for corneal infiltrative and inflammatory events (CIEs) in young, soft contact lens (SCL) wearers and to model the age-related risk.METHODS. A multicenter, retrospective chart review of 3549 SCL wearers (8-33 years at first observed visit, + 8.00 to - 12.00D, oversampling < 18 years) captured CIEs from January 2006 to September 2009. The review noted age, sex, SCL worn, use of lens care products, and SCL wearing history. Event diagnoses were adjudicated to consensus by reviewers masked to wearer identity, age, and SCL parameters. Significant univariate risk factors for CIEs were subsequently tested in multivariate generalized estimating equations.RESULTS. Charts from 14,305 visits observing 4,663 SCL years yielded 187 CIEs in 168 wearers. Age was a significant nonlinear risk factor, peaking between 15 and 25 years (P < 0.008). Less than 1 year of SCL use was protective versus longer years of wear (P < 0.0003). Use of multipurpose care products (2.86 x), silicone hydrogels (1.85 x), and extended wear (2.37 x) were significantly associated with CIEs in the multivariate model (P < 0.0001 each).CONCLUSIONS. Patient age, years of lens wear, use of multipurpose care products, silicone hydrogels, and extended wear were all significantly associated with CIEs with SCL wear. Use of SCLs in young patients aged 8 to 15 years was associated with a lower risk of infiltrative events compared with teens and young adults. In terms of safety outcomes, SCLs appear to be an acceptable method of delivering optics designed to manage myopia progression in children and young teens in the future. (Invest Ophthalmol Vis Sci. 2011; 52: 6690-6696) DOI: 10.1167/iovs.10-7018