Serum Levels of Anti-Mullerian Hormone as a Marker of Ovarian Function in 926 Healthy Females from Birth to Adulthood and in 172 Turner Syndrome Patients
Serum Levels of Anti-Mullerian Hormone as a Marker of Ovarian Function in 926 Healthy Females from Birth to Adulthood and in 172 Turner Syndrome Patients
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DOI：
10.1210/jc.2010-0930
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发表时间：
2010-11-01
影响因子：
5.8
通讯作者：
Juul, Anders
中科院分区：
文献类型：
--
作者：
Hagen, Casper P.;Aksglaede, Lise;Juul, Anders
背景：在成年女性中，抗苗勒氏管激素 (AMH) 与卵巢卵泡池有关。人们对女孩中的 AMH 知之甚少。 目的：本研究的目的是为女孩和青少年的 AMH 提供参考范围，并评估 AMH 作为卵巢功能的标志物。背景：该研究是在儿科内分泌三级转诊中心进行的。主要结果指标：我们根据年龄、年龄、性别对 926 名健康女性（婴儿期的纵向值）以及 172 名特纳综合征 (TS) 患者进行了 AMH 测量。核型（A：45，X；B：杂核型；C：45，X/46，XX）和卵巢功能（1：青春期缺失；2：卵巢功能停止；3：卵巢功能持续）。结果：54%（71 份中的 38 份）脐带血样本中未检测到 AMH（
Context: In adult women, anti-Mullerian hormone (AMH) is related to the ovarian follicle pool. Little is known about AMH in girls.Objective: The objective of the study was to provide a reference range for AMH in girls and adolescents and to evaluate AMH as a marker of ovarian function.Setting: The study was conducted at a tertiary referral center for pediatric endocrinology.Main Outcome Measures: We measured AMH in 926 healthy females (longitudinal values during infancy) as well as in 172 Turner syndrome (TS) patients according to age, karyotype (A: 45, X; B: miscellaneous karyotypes; C: 45, X/46, XX), and ovarian function (1: absent puberty; 2: cessation of ovarian function; 3: ongoing ovarian function).Results: AMH was undetectable in 54% (38 of 71) of cord blood samples (