Regioselectivity in Lewis acids catalyzed X-H (O, S, N) insertions of methyl styryldiazoacetate with benzyl alcohol, benzyl thiol, and aniline
Regioselectivity in Lewis acids catalyzed X-H (O, S, N) insertions of methyl styryldiazoacetate with benzyl alcohol, benzyl thiol, and aniline
复制标题
DOI：
10.1016/j.tetlet.2007.04.046
复制
发表时间：
2007-06-04
影响因子：
1.8
通讯作者：
Hu, Wenhao
中科院分区：
文献类型：
--
作者：
Yue, Yongli;Wang, Yuanhua;Hu, Wenhao
与Rh（II）催化剂不同，Cu（I）、Cu（IT）和Ag（I）等刘易斯酸催化苯乙烯基重氮乙酸甲酯的X-H（X = O，S，N）插入反应优先发生在γ位。在反应中仅观察到（E）-异构体。该方法为γ-羟基或γ-氨基酸衍生物的合成提供了一种替代方法。(c)2007爱思唯尔有限公司保留所有权利。
Different from Rh(II) catalysts, X-H (X = O, S, N) insertion of methyl styryldiazoacetate catalyzed by Lewis acids including Cu(I), Cu(IT) and Ag(I) complexes occurred at gamma-position preferably. Only (E)-isomer was observed in the reactions. This method provides an alternative for the synthesis of gamma-hydroxyl or gamma-amino acid derivatives. (c) 2007 Elsevier Ltd. All rights reserved.