IMPORTANCE OF HYPOGLYCEMIA-INDUCED GLUCOSE-PRODUCTION DURING ISOLATED GLUCAGON DEFICIENCY
IMPORTANCE OF HYPOGLYCEMIA-INDUCED GLUCOSE-PRODUCTION DURING ISOLATED GLUCAGON DEFICIENCY
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DOI：
10.1152/ajpendo.1979.236.3.e263
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
LACY, WW
中科院分区：
文献类型：
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作者：
CHERRINGTON, AD;LILJENQUIST, JE;LACY, WW
研究是为了评估身体弥补胰高血糖素缺乏的能力。将生长抑素和基础替代量的胰岛素注入隔夜禁食的狗4.5h，造成长期的胰升糖素缺乏期。用预先恒定输注[~3H]葡萄糖的方法测量葡萄糖产量(GP)，通过测量循环中丙氨酸和乳酸向葡萄糖的转化来评估葡萄糖异生作用(GNG)。缺乏4小时的胰升糖素与28.+-相关。整体总分持续下降4%，为136.+-。GNG增长49%，GNG为39.%+-。5 mg/dl可降低血糖水平。当静脉输注葡萄糖预防因胰升糖素缺乏引起的低血糖时，内源性GP下降67.7%，GNG保持轻度抑制(20%)。在吸收后的狗中，基础胰高血糖素负责超过2/3的GP，其主要作用是刺激糖原分解。胰岛素存在时，基础胰高血糖素对于维持正常血糖和正常血糖是必不可少的。在这种情况下，选择性胰高血糖素缺乏症所伴随的低血糖在维持GP和限制葡萄糖利用方面起着重要作用。低血糖诱导的GP刺激涉及糖原分解和糖异生反应。
Studies were undertaken to assess the ability of the body to compensate for glucagon lack. Somatostatin and basal replacement amounts of insulin were infused into overnight fasted dogs for 4.5 h to create a period of prolonged glucagon deficiency. Glucose production (GP) was measured using a primed constant infusion of [3H]glucose and gluconeogenesis (GNG) was assessed by measuring the conversion of circulating alanine and lactate into glucose. Glucagon lack of 4 h duration was associated with a 28 .+-. 4% sustained fall in overall GP, a 136 .+-. 49% increase in GNG and a 39 .+-. 5 mg/dl decrease in the plasma glucose level. When the hypoglycemia attendant on glucagon lack was prevented by the infusion of glucose, endogenous GP decreased by 67 .+-. 7% and GNG remained mildly suppressed (20%). In postabsorptive dogs basal glucagon is responsible for over 2/3 of GP, its primary role being a stimulation of glycogenolysis. Basal glucagon is essential for the maintenance of normal GP and euglycemia when insulin is present. The hypoglycemia attendant on selective glucagon deficiency plays an important role in maintaining GP and limiting glucose utilization under this circumstance. The stimulation of GP induced by hypoglycemia involves a glycogenolytic and gluconeogenic response.