Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients.
Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients.
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DOI：
10.4103/1735-3327.201138
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发表时间：
2017-01
影响因子：
--
通讯作者：
Kuberappa PH
中科院分区：
文献类型：
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作者：
Bagalad BS;Mohankumar KP;Madhushankari GS;Donoghue M;Kuberappa PH
由于慢性衰弱性疾病的增加和人口年龄的增长，慢性肾衰竭的患病率正在上升。这些患者经历代谢副产物的积累和电解质失衡，这对他们的健康有有害的影响。对这些患者来说，定期进行及时的血液透析是挽救生命的手段。唾液诊断越来越多地被用作传统方法的替代方法。因此，本研究的目的是确定唾液在慢性肾功能衰竭患者中的诊断功效。这项病例对照研究包括82名个体，其中41名是慢性肾衰竭患者，41名是年龄和性别匹配的对照组。收集血液和唾液并离心。血清和唾液上清进行生化分析。采用非配对t检验、Pearson相关系数、诊断效度检验和患者手术曲线评价慢性肾功能衰竭患者血清和唾液尿素、肌酐、钠、钾、钙、磷的相关性。与血清相比；根据研究结果，唾液尿素、肌酐、钠和钾的诊断准确率分别为93%、91%、73%和89%。由此可见，唾液检查是一种可靠、无创、无传染性、简便、快速的筛查高危患者矿物质和代谢物值、监测肾功能衰竭患者的方法。
The prevalence of chronic renal failure is increasing because of increase in chronic debilitating diseases and progressing age of population. These patients experience accumulation of metabolic byproducts and electrolyte imbalance, which has harmful effects on their health. Timely hemodialysis at regular intervals is a life-saving procedure for these patients. Salivary diagnostics is increasingly used as an alternative to the traditional methods. Thus, the aim of the present study was to determine the diagnostic efficacy of saliva in chronic renal failure patients. This case–control study included 82 individuals, of which 41 were chronic renal failure patients and 41 were age- and sex-matched controls. Blood and saliva were collected and centrifuged. Serum and supernatant saliva were used for biochemical analysis. Serum and salivary urea, creatinine, sodium, potassium, calcium, and phosphorus were evaluated and correlated in chronic renal failure patients using unpaired t-test, Pearson's correlation coefficient, diagnostic validity tests, and receiver operative curve. When compared to serum; salivary urea, creatinine, sodium, and potassium showed diagnostic accuracy of 93%, 91%, 73%, and 89%, respectively, based on the findings of study. It can be concluded that salivary investigation is a dependable, noninvasive, noninfectious, simple, and quick method for screening the mineral and metabolite values of high-risk patients and monitoring the renal failure patients.