Zinc may be a mediator of leptin production in humans
Zinc may be a mediator of leptin production in humans
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DOI：
10.1016/s0024-3205(00)00541-5
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发表时间：
2000-04-21
期刊：
影响因子：
6.1
通讯作者：
Lin, PY
中科院分区：
文献类型：
--
作者：
Chen, MD;Song, YM;Lin, PY
肥胖者有高瘦素血症和低锌血症。此外，瘦素和锌在循环中的浓度有昼夜变化。我们调查了他们可能的相互作用，并检查了肥胖男性和他们的瘦对照组之间是否存在差异。结果表明，肥胖组和瘦肉组的血锌和瘦素昼夜变化规律无明显差异。然而，在每个采样时间，肥胖者的瘦素水平高于瘦肉组，而锌血浆水平低于瘦肉组。由于锌与瘦素的血浆水平呈负相关(r=-0.51，p=0.012)，我们进一步确定了锌在女性供者皮下脂肪组织产生瘦素中可能起的作用。体外实验表明，锌处理组(0.2 mmoL/L)显著增加瘦素生成(142%)，但增幅不超过胰岛素组(10nmoL/L)。这项研究的数据表明锌和瘦素之间存在互动关系。
Obese individuals have hyperleptinemia and hypozincemia. Moreover, leptin and zinc have circadian changes in circulating concentrations. We investigated their possible interaction and examined whether a difference existed between obese men and their lean controls. The results indicated the pattern of circadian change in plasma zinc and leptin did not markedly differ between the obese subjects and the lean controls. However, the obese had higher leptin and lower zinc plasma values at each sampling time than did the lean controls. Because an inverse correlation was found in plasma values between zinc and leptin (r=-0.51, p=0.012), we further determined the role zinc might play in leptin production by human subcutaneous adipose tissue from female donors. The in vitro study showed that zinc treatment (0.2 mmol/L) significantly increased leptin production (142%), however, this increment did not surpass that by insulin (10 nmol/L). The data of this study suggest an interactive connection between zinc and leptin.