Anti aldol reactions of alpha-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin.
Anti aldol reactions of alpha-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin.
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DOI：
10.1016/0040-4039(96)01879-5
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发表时间：
1996-11-04
影响因子：
1.8
通讯作者：
Nowak, T
中科院分区：
文献类型：
--
作者：
Paterson, I;Nowak, T
以酮（S）-8为原料，经12步反应制得抗真菌剂（+）-局限菌素（1）。关键步骤是（i）硼介导的（S）-8与9的反羟醛缩合反应，得到13和（ii）环化反应4->5。版权所有（C）1996 Elsevier Science Ltd.
The antifungal agent (+)-restricticin (1) was prepared in 12 steps from ketone (S)-8. The key steps are (i) the boron-mediated anti aldol reaction of (S)-8 with 9 to give 13 and (ii) the cyclisation reaction 4->5. Copyright (C) 1996 Elsevier Science Ltd.