The value of nonhuman primate animal models in anti-HIV drug studies
The value of nonhuman primate animal models in anti-HIV drug studies
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发表时间：
2007
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通讯作者：
Zheng Yong-tang
中科院分区：
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作者：
Zheng Yong-tang
非人灵长类动物模型广泛应用于HIV研究，SIV/猕猴模型和SHIV/猕猴模型已被广泛应用于研究，除了在艾滋病发病机制和抗HIV疫苗的研究中发挥重要作用外，在抗HIV药物评价中显示出更实用和适应性更强的应用：药物治疗的有效性，新药的开发，药物的研究，研究抗病毒药物的体内抗病毒疗效及作用机制，将有助于进一步完善现有药物的治疗方法治疗，指导未来的人体临床试验，并引发对抗逆转录病毒药物治疗原则和药物评价标准的新思考。
Nonhuman primate animal models are widely used in HIV research.SIV/macaque models and SHIV/macaque models have been used extensively for studies.Besides playing an important role in the research for AIDS pathogenesis and anti-HIV vaccines,they displayed a more practical and adaptable application in evaluation of anti-HIV drug:the efficacy of drug therapy,the exploitation of new drugs,the researches of drug-resistant and the role of antiviral immune responses during drug therapy.The research of antiviral efficacy and mechanism in vivo will lead to further recognitions for current drug therapy,guide future human clinical trials,and lead to new consideration for antiretroviral drug therapy principle and drug evaluation standard.