Is it possible folic acid reduce anorectal malformations ethylenethiourea induced in rats?
Is it possible folic acid reduce anorectal malformations ethylenethiourea induced in rats?
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DOI：
10.1590/s0102-865020150080000001
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发表时间：
2015-08-01
影响因子：
1.1
通讯作者：
Martins, José Luiz
中科院分区：
文献类型：
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作者：
Faria, Danilo José Fiorindo;Simões, Manuel de Jesus;Martins, José Luiz
目的：探讨叶酸（FA）对乙基乙硫脲（ETU）诱导的肛肠畸形（ARMs）实验模型的影响。方法：8只雌性Wistar大鼠随机分为两组。A组- ETU；B组- FA+ETU；B组从妊娠前2周起至妊娠结束，每天灌胃FA （50 mg/kg）。A组和B组于妊娠第11天灌胃1% ETU （125 mk/kg）。他们的胎儿在GD21剖宫产，并检查寻找ARMs。分析肛门分层鳞状上皮（ASSE）和肠上皮（IE）的厚度。p
PURPOSE: To investigate the effect of folic acid (FA) in an experimental model of anorectal malformations (ARMs) ethylenethiourea (ETU) induced.METHODS: Eight female Wistar rats were divided randomly in two groups. Group A - ETU; Group B - FA+ETU; Dams from group B received daily, since two weeks before pregnancy to the end of pregnancy, FA (50 mg/kg) by gavage. Dams from groups A and B, received 1% ETU (125 mk/kg) by gavage on gestational day (GD) 11. Their fetuses were harvested by cesarean section on GD21 and were examined looking for ARMs. The thickness of anal stratified squamous epithelium (ASSE) and intestinal epithelium (IE) were analyzed. p