SAFETY OF CASEIN HYDROLYSATE FORMULA IN CHILDREN WITH COW MILK ALLERGY
SAFETY OF CASEIN HYDROLYSATE FORMULA IN CHILDREN WITH COW MILK ALLERGY
复制标题
DOI：
10.1016/s0022-3476(05)90001-2
复制
发表时间：
1991-04-01
影响因子：
5.1
通讯作者：
SCANLON, SM
中科院分区：
文献类型：
--
作者：
SAMPSON, HA;BERNHISELBROADBENT, J;SCANLON, SM
这项研究的目的是确定一种新的酪蛋白水解物婴儿配方奶粉Alimentum是否可以安全地用于牛奶过敏儿童。用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳法和灵敏的酶联抑制免疫分析法对配方进行分析，判定该配方用于牛奶过敏儿童临床试验是安全的。25名这样的儿童接受了双盲、安慰剂对照的口服食物挑战，他们服用了10克牛奶粉和酪蛋白水解物配方。所有的儿童都是高度过敏的，对牛奶有阳性的皮肤刺痛反应。在双盲、安慰剂对照的食物挑战中，没有患者对安慰剂有反应。两名患者对牛奶失去过敏，在挑战期间没有反应；其余患者在挑战后15至90分钟内出现各种皮肤、呼吸道和胃肠道症状。所有儿童都能忍受对酪蛋白水解物的盲目挑战，并毫无困难地公开喂食该水解物。我们的结论是，这种酪蛋白水解物对于对牛奶即刻过敏的儿童来说通常是安全的。除了标准的营养评估和动物抗原性测试外，我们建议在牛奶过敏患者中测试所有被宣传为“低过敏性”的婴儿配方奶粉，以评估他们的过敏潜力。
The purpose of this study was to determine whether a new casein hydrolysate infant formula, Alimentum, could be administered safely to children with cow milk hypersensitivity. The formula was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and with a sensitive enzyme-linked inhibition immunoassay, and it was judged to be safe for clinical trials in children allergic to cow milk. Twenty-five such children underwent double-blind, placebo-controlled oral food challenges with 10 gm of powdered cow milk and casein hydrolysate formula. All children were highly atopic and had positive skin prick reactions to cow milk. No patient reacted to placebo during a double-blind, placebo-controlled food challenge. Two patients lost their allergy to cow milk and did not react during the challenge; the remaining patients reacted with a variety of cutaneous, respiratory, and gastrointestinal symptoms within 15 to 90 minutes of challenge. All children tolerated the blinded challenge to the casein hydrolysate and were fed the hydrolysate openly without difficulty. We conclude that this casein hydrolysate is generally safe to feed to children with immediate hypersensitivity to cow milk. We recommend that all infant formulas promoted as "hypoallergenic" be tested in milk-allergic patients to assess their allergenic potential, in addition to standard nutritional evaluation and animal testing for antigenicity.