Cannabis-induced psychosis-like experiences are associated with high schizotypy
Cannabis-induced psychosis-like experiences are associated with high schizotypy
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DOI：
10.1159/000092678
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发表时间：
2006-01-01
期刊：
影响因子：
3.6
通讯作者：
Lewis, S.
中科院分区：
文献类型：
--
作者：
Barkus, E. J.;Stirling, J.;Lewis, S.
目的：最近的研究表明，大麻使用是精神分裂症的一个危险因素。我们测试了一个假设，即大麻的使用增加了非临床参与者中精神病样经历的可能性，这些参与者在一项精神病类型测量中得分很高。法大麻的心理影响进行了评估，在137个健康的人（76%的女性，平均年龄22岁）使用一个新开发的问卷有关的主观经验的药物：大麻经验问卷。问卷分为三个分量表：愉快体验、精神病样体验和后遗症。受访者还完成了简短的分裂型人格问卷。结果：72%的样本报告使用大麻。使用本身与异型性无显著相关。然而，高得分的大麻类型更有可能报告与大麻使用相关的精神病样经历和不愉快的后遗症。大麻使用的愉悦效果与神经型评分无关。结论：使用大麻的高得分的大麻类型更有可能在使用时经历类似精神病的现象，以及令人不快的后遗症。我们的研究结果与假设一致，即大麻使用是该组完全精神病的危险因素。
Objective: Recent studies have suggested that cannabis use is a risk factor for developing schizophrenia. We tested the hypothesis that cannabis use increases the likelihood of psychosis-like experiences in non-clinical participants who scored highly on a measure of schizotypy. Method. The psychological effects of cannabis were assessed in 137 healthy individuals (76% female, mean age 22 years) using a newly developed questionnaire concerned with subjective experiences of the drug: the Cannabis Experiences Questionnaire. The questionnaire has three subscales: Pleasurable Experiences, Psychosis-Like Experiences and After-Effects. Respondents also completed the brief Schizotypal Personality Questionnaire. Results: Cannabis use was reported by 72% of the sample. Use per se was not significantly related to schizotypy. However, high scoring schizotypes were more likely to report both psychosis-like experiences and unpleasant after-effects associated with cannabis use. The pleasurable effects of cannabis use were not related to schizotypy score. Conclusion: High scoring schizotypes who use cannabis are more likely to experience psychosis-like phenomena at the time of use, and unpleasant after-effects. Our results are consistent with the hypothesis that cannabis use is a risk factor for full psychosis in this group.