μ-Suppression during Action Observation and Execution Correlates with BOLD in Dorsal Premotor, Inferior Parietal, and SI Cortices
μ-Suppression during Action Observation and Execution Correlates with BOLD in Dorsal Premotor, Inferior Parietal, and SI Cortices
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DOI：
10.1523/jneurosci.0963-11.2011
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发表时间：
2011-10-05
影响因子：
5.3
通讯作者：
Gazzola, Valeria
中科院分区：
文献类型：
--
作者：
Arnstein, Dan;Cui, Fang;Gazzola, Valeria
在猴子身上发现的镜像神经元，在执行和观察同一个动作时都会被激活，这引发了人们对研究人类镜像神经元的极大兴趣。十多年来，功能性磁共振成像（fMRI）和脑电图（EEG）都被用来量化人类镜像神经元系统（MNS）的活动-然而，对MNS的fMRI和EEG测量如何相互关联仍然知之甚少。为了测试频繁的假设，即由fMRI证明的MNS区域是动作执行和观察期间EEG μ节律抑制的起源，我们同时记录了EEG和BOLD-fMRI信号，而参与者观察和执行动作。我们发现，在动作观察和执行过程中，EEG中μ节律的抑制与典型的MNS区域，下顶叶（IPL），背运动前区（dPM）和初级体感皮层（BA 2）的BOLD活动共变。相比之下，在BA 44中，在观察和执行期间，只有不重叠的体素与μ抑制相关。这些发现提供了直接支持的概念，μ抑制是一个有效的指标MNS活动在BA 2，IPL和dPM，但反对的想法，在BA 44镜像神经元的μ抑制的主要来源。这些结果揭示了μ抑制的神经基础，并提供了一个基础，更紧密地整合蓬勃发展，但往往单独的文献MNS使用功能磁共振成像和脑电图。
The discovery of mirror neurons in the monkey, that fire during both the execution and the observation of the same action, sparked great interest in studying the human equivalent. For over a decade, both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have been used to quantify activity in the human mirror neuron system (MNS)-yet, little is still known about how fMRI and EEG measures of the MNS relate to each other. To test the frequent assumption that regions of the MNS as evidenced by fMRI are the origin of the suppression of the EEG mu-rhythm during both action execution and observation, we recorded EEG and BOLD-fMRI signals simultaneously while participants observed and executed actions. We found that the suppression of the mu-rhythm in EEG covaried with BOLD activity in typical MNS regions, inferior parietal lobe (IPL), dorsal premotor (dPM) and primary somatosensory cortex (BA2), during both action observation and execution. In contrast, in BA44, only nonoverlapping voxels correlated with mu-suppression during observation and execution. These findings provide direct support for the notion that mu-suppression is a valid indicator of MNS activity in BA2, IPL, and dPM, but argues against the idea that mirror neurons in BA44 are the prime source of mu-suppression. These results shed light on the neural basis of mu-suppression and provide a basis for integrating more closely the flourishing but often separate literatures on the MNS using fMRI and EEG.