Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum
Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum
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Klyflaccilides A 和 B，来自海南软珊瑚 Klyxum flaccidum 的具有 6/5/8/3 稠合四环碳骨架的二萜类化合物
DOI：
10.1021/acs.orglett.9b01998
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发表时间：
2019-07-19
期刊：
影响因子：
5.2
通讯作者：
Li, Xu-Wen
中科院分区：
文献类型：
--
作者：
Li, Geng;Li, Heng;Li, Xu-Wen
从海南软珊瑚Klyxum flaccidum中分离得到两个新的多氧二萜化合物klyflaccilides A（1）和B（2），均为6/5/8/3四环结构。它们的结构通过广泛的光谱分析、X射线衍射分析和/或量子化学计算方法确定。进一步提出了1和2与其潜在前体3的合理生物合成关系。化合物1和3通过抑制LPS诱导的TNF-α蛋白释放而显示出中等的抗炎活性。
Two novel polyoxygenated diterpenoids, klyflaccilides A (1) and B (2), featuring an uncommon 6/5/8/3 tetracyclic ring system, were isolated from the Hainan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or a quantum chemical computation method. A plausible biosynthetic relationship of 1 and 2 with their potential precursor 3 was further proposed. Compounds 1 and 3 exhibited moderate anti-inflammatory activity by the inhibition of LPS-induced TNF-alpha protein release.