The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind.
The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind.
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DOI：
10.2174/1570159x15666170116143743
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发表时间：
2017
影响因子：
5.3
通讯作者：
Fedele E
中科院分区：
文献类型：
--
作者：
Ricciarelli R;Fedele E
自 1984 年被发现以来，β 淀粉样肽一直作为阿尔茨海默病发病机制中的明星分子出现在神经科学领域。然而，在过去的十年中，这一愿景受到了循证医学的挑战，这些证据表明，充满希望的抗淀粉样蛋白疗法的临床试验几乎完全失败。此外，积累的数据清楚地表明这种小肽在记忆形成的生理过程中发挥着关键作用。在本综述中，我们将讨论淀粉样蛋白级联假说的不同方面，强调其优点和缺点，并将分析迄今为止尝试的治疗方法的结果，这些方法应该会改变未来阿尔茨海默病的研究方向。
Since its discovery in 1984, the beta amyloid peptide has treaded the boards of neurosciences as the star molecule in Alzheimer’s disease pathogenesis. In the last decade, however, this vision has been challenged by evidence-based medicine showing the almost complete failure of clinical trials that experimented anti-amyloid therapies with great hopes. Moreover, data have accumulated which clearly indicate that this small peptide plays a key role in the physiological processes of memory formation. In the present review, we will discuss the different aspects of the amyloid cascade hypothesis, highlighting its pros and cons, and we will analyse the results of the therapeutic approaches attempted to date that should change the direction of Alzheimer’s disease research in the future.