Temporal modulation of spike-timing-dependent plasticity.
Temporal modulation of spike-timing-dependent plasticity.
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DOI：
10.3389/fnsyn.2010.00019
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发表时间：
2010
影响因子：
3.7
通讯作者：
Bi GQ
中科院分区：
文献类型：
--
作者：
Froemke RC;Debanne D;Bi GQ
尖峰时间相关塑性(STDP)在过去的十年中引起了相当大的实验和理论关注。在最基本的公式中，STDP提供了一个基本单位--棘波对--用于量化突触强度长期变化的诱导。然而，许多因素，包括突触前和突触后，都可以影响突触的传递和整合，特别是当考虑到多个棘波时。在这里，我们回顾了STDP中多种类型的非线性时间相互作用的实验证据，重点是单个棘波对、总的棘波频率和精确的棘波计时对皮层和海马兴奋性突触的修饰的贡献。我们讨论了决定不同突触特定学习规则的潜在过程，如突触后兴奋性和短期抑郁。最后，我们描述了建立预测的、定量的模型的努力的成功，该模型描述了复杂和自然的棘波训练如何导致长期的突触修改。
Spike-timing-dependent plasticity (STDP) has attracted considerable experimental and theoretical attention over the last decade. In the most basic formulation, STDP provides a fundamental unit – a spike pair – for quantifying the induction of long-term changes in synaptic strength. However, many factors, both pre- and postsynaptic, can affect synaptic transmission and integration, especially when multiple spikes are considered. Here we review the experimental evidence for multiple types of nonlinear temporal interactions in STDP, focusing on the contributions of individual spike pairs, overall spike rate, and precise spike timing for modification of cortical and hippocampal excitatory synapses. We discuss the underlying processes that determine the specific learning rules at different synapses, such as postsynaptic excitability and short-term depression. Finally, we describe the success of efforts toward building predictive, quantitative models of how complex and natural spike trains induce long-term synaptic modifications.