Adherence to HAART among HIV-infected persons in rural Louisiana
Adherence to HAART among HIV-infected persons in rural Louisiana
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DOI：
10.1089/108729104323076025
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发表时间：
2004-05-01
影响因子：
4.9
通讯作者：
Kissinger, P
中科院分区：
文献类型：
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作者：
Mohammed, H;Kieltyka, L;Kissinger, P
本研究的目的是检查与非城市路易斯安那州HIV诊所的患者不依从高效抗逆转录病毒治疗（HAART）相关的因素。一个方便的样本273例患者从8个地区在非城市路易斯安那州进行了采访，以获得人口统计学，临床和依从性信息。研究人口统计学、临床和行为因素与不依从之间的关系。理想情况下，HAART处方患者的不依从性不应超过5%。平均年龄为38.6岁（范围：19-66岁），29.3%为女性，60.1%为非洲裔美国人，34.4%报告不依从HAART药物治疗（定义为受试者自我报告前一周缺失任何剂量的HAART药物治疗）。在上个月，参与者报告了以下行为：酗酒（12.8%），问题饮酒（12.8%）和非法药物使用（16.5%）。49.8%的受访者患有抑郁症。Logistic回归分析发现，问题饮酒与不依从性相关的OR（95%可信区间）为3.92（1.69，9.09）。人口统计学和行为因素，如非法药物使用和抑郁症与不遵守多变量分析。问题饮酒与过去一周缺乏HAART依从性有关。需要采取干预措施来治疗饮酒问题，并可能改善居住在农村、城镇和小城市地区的艾滋病毒感染者的药物治疗依从性。
The purpose of this study was to examine factors associated with nonadherence to highly active antiretroviral therapy (HAART) in patients seen in HIV clinics throughout nonurban Louisiana. A convenience sample of 273 patients from 8 areas in nonurban Louisiana were interviewed to obtain demographic, clinical and adherence information. Associations between demographic, clinical, and behavioral factors and nonadherence were examined. Ideally, nonadherence should not exceed 5% in patients for whom HAART was prescribed. Mean age was 38.6 years (range, 19-66), 29.3% were female, 60.1% were African American, 34.4% reported nonadherence to their HAART medication (defined as the subject's self-report of missing any doses of HAART medication in the prior week). In the prior month, participants reported the following behaviors: binge drinking (12.8%), problem drinking (12.8%), and illicit drug use (16.5%). Depression was found in 49.8% of the respondents. In logistic regression analysis, problem drinking odds ratio [OR] (95% confidence interval [CI]): 3.92 (1.69,9.09) was found to be associated with nonadherence. Demographic and behavioral factors such as illicit drug use and depression were not associated with nonadherence on multivariable analysis. Problem drinking was associated with lack of adherence to HAART over the past week. Interventions to treat problem drinking are needed and may improve adherence to medication for HIV-infected persons living in rural, town, and small-city areas.