MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome
MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome
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DOI：
10.1016/j.sleep.2005.11.009
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发表时间：
2006-08-01
期刊：
影响因子：
4.8
通讯作者：
Allen, Richard P.
中科院分区：
文献类型：
--
作者：
Earley, Christopher J.;Barker, Peter B.;Allen, Richard P.
目的：脑脊液（CSF），磁共振成像（MRI）和尸检研究表明，脑铁可能减少不宁腿综合征（RLS）。对数据的进一步分析还表明，脑铁减少可能选择性地用于早发性RLS。这项研究旨在复制和扩展我们以前的研究结果，特别是关于早发性RLS。在这项研究中，我们的主要假设是，黑质（SN）铁指数将在早发性RLS降低controls.Methods：铁浓度或“铁指数”在10个脑区使用MRI确定在39个对照组和22早发性和19晚发性RLS受试者。使用约翰·霍普金斯RLS严重程度（JHRLSS）量表来定义疾病严重程度。结果：与对照组相比，早发性RLS的SN平均铁指数显着降低（t = 2.5，P = 0.016），而晚发性RLS和对照组无差异。对照组早发型RLS队列SN铁指数与JHRLSS量表之间存在显著的负斯皮尔曼等级相关性（rho =-0.32，P = 0.016）。结论：当前MRI结果结合既往尸检数据支持至少在早发型RLS症状患者SN中低脑铁的作用。(c)2005 Elsevier B. V.保留所有权利。
Objective: Cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) and autopsy studies have suggested that brain iron may be reduced in restless legs syndrome (RLS). Further analysis of the data also suggests that diminished brain iron may selectively be for early-onset RLS. This study was designed to replicate and extend our previous findings, specifically with regard to early-onset RLS. In this study our primary hypothesis was that substantia nigra (SN) iron index would be decreased in early-onset RLS compared to controls.Methods: The iron concentration or `iron index' in 10 brain regions was determined using MRI in 39 controls and in 22 early-onset and 19 late-onset RLS subjects. The Johns Hopkins RLS severity (JHRLSS) scale was used to define disease severity.Results: The mean iron index from the SN was significantly lower in the early-onset RLS compared to controls (t = 2.5, P = 0.016), while late-onset RLS and controls did not differ. There was a significant negative Spearman rank correlation between SN iron index and JHRLSS scale for the control-early-onset-RLS cohort (rho = -0.32, P = 0.016).Conclusions: The current MRI results in combination with previous autopsy data support the role of low brain iron in the SN in at least those with early-onset RLS symptoms. (c) 2005 Elsevier B.V. All rights reserved.